Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/141941
Title: | Lipid raft aging in the human frontal cortex during nonpathological aging: gender influences and potential implications in Alzehimer's disease |
Author: | Díaz, Mario Fabelo, Noemí Ferrer, Isidro (Ferrer Abizanda) Marín, Raquel |
Keywords: | Envelliment Metabolisme Malaltia d'Alzheimer Etiologia Escorça cerebral Aging Metabolism Alzheimer's disease Etiology Cerebral cortex |
Issue Date: | 1-Jul-2018 |
Publisher: | Elsevier B.V. |
Abstract: | Lipid rafts are highly dynamic membrane domains featured by distinctive biochemical composition and physicochemical properties compared with the surrounding plasma membrane. These microstructures are associated not only with cellular signaling and communication in normal nerve cells but also with pathological processing of amyloid precursor protein in Alzheimer's disease. Using lipid rafts isolated from human frontal cortex in nondemented subjects aging 24 to 85 years, we demonstrate here that lipid structure of lipid rafts undergo significant alterations of specific lipid classes and phospholipid-bound fatty acids as brain cortex correlating with aging. Main changes affect levels of plasmalogens, polyunsaturated fatty acids (especially docosahexaenoic acid and arachidonic acid), total polar lipids (mainly phosphatidylinositol, sphingomyelin, sulfatides, and cerebrosides), and total neutral lipids (particularly cholesterol and sterol esters). Besides, relevant relationships between main fatty acids and/or lipid classes were altered in an age-related manner. This 'lipid raft aging' exhibits clear gender differences and appear to be more pronounced in women than in men, especially in older (postmenopausal) women. The outcomes led us to conclude that human cortical lipid rafts are modified by aging in a gender-dependent fashion. Given the central role of bilayer lipid matrix in lipid rafts functionality and neuronal signaling, we hypothesize that these findings might underlie the higher prevalence of cognitive decline evolving toward Alzheimer's disease in postmenopausal women. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.neurobiolaging.2018.02.022 |
It is part of: | Neurobiology of Aging, 2018, vol. 67, p. 42-52 |
URI: | http://hdl.handle.net/2445/141941 |
Related resource: | https://doi.org/10.1016/j.neurobiolaging.2018.02.022 |
ISSN: | 0197-4580 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
689413.pdf | 2.87 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License