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http://hdl.handle.net/2445/143362
Title: | Enantioselective Synthesis of β-Methyl Amines via Iridium-Catalyzed Asymmetric Hydrogenation of N-Sulfonyl Allyl Amines. |
Author: | Cabré Montesinos, Albert Verdaguer i Espaulella, Xavier Riera i Escalé, Antoni |
Keywords: | Iridi Catàlisi asimètrica Hidrogenació Síntesi de fàrmacs Iridium Enantioselective catalysis Hydrogenation Drug synthesis |
Issue Date: | 5-Aug-2019 |
Publisher: | Wiley-VCH |
Abstract: | The iridium-catalyzed asym. hydrogenation of several N-sulfonyl allyl amines was reported. All substrates could be easily obtained by the Ir-catalyzed isomerization of N-tosylaziridines reported previously. The com. available threonine-derived phosphinite (UbaPHOX) iridium complex had been found to be the best catalyst for this catalytic application, affording β-Me amines I [R1 = H, 4-Cl, 4-Br, etc.;R2 = Me, i-Pr, 4-MeC6H4; R3 = H, Me] with good to excellent ee values (up to 94%). The synthetic potential of this novel methodol. was demonstrated by the formal synthesis of Lorcaserin and LY-404187. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/adsc.201900748 |
It is part of: | Advanced Synthesis & Catalysis, 2019, vol. 361, num. 18, p. 4196-4200 |
URI: | http://hdl.handle.net/2445/143362 |
Related resource: | https://doi.org/10.1002/adsc.201900748 |
ISSN: | 1615-4150 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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