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http://hdl.handle.net/2445/143378| Title: | Evaluation of logPo/w values of drugs from some molecular structure calculation software |
| Author: | Pallicer Santana, Juan Manuel Rosés Pascual, Martí Ràfols Llach, Clara Bosch, Elisabeth Pascual, Rosalía Port, Ariadna |
| Keywords: | Lipofília Química farmacèutica Lipophilicity Pharmaceutical chemistry |
| Issue Date: | 2014 |
| Publisher: | IAPC Publishing |
| Abstract: | The iridium‐catalyzed asymmetric hydrogenation of several N‐sulfonyl allyl amines is reported. All substrates can be easily obtained by the Ir‐catalyzed isomerization of N‐tosylaziridines reported previously. The commercially available threonine‐derived phosphinite (UbaPHOX) iridium complex has been found to be the best catalyst for this catalytic application, affording β‐methyl amines with good to excellent ee values (up to 94%). The synthetic potential of this novel methodology was demonstrated by the formal synthesis of Lorcaserin and LY‐404187. |
| Note: | Reproducció del document publicat a: https://doi.org/10.5599/admet.2.2.45 |
| It is part of: | ADMET & DMPK, 2014, vol. 2, num. 2, p. 107-114 |
| URI: | http://hdl.handle.net/2445/143378 |
| Related resource: | https://doi.org/10.5599/admet.2.2.45 |
| ISSN: | 1848-7718 |
| Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 643435.pdf | 1.07 MB | Adobe PDF | View/Open |
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