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Title: Evaluation of logPo/w values of drugs from some molecular structure calculation software
Author: Pallicer Santana, Juan Manuel
Rosés Pascual, Martí
Ràfols Llach, Clara
Bosch, Elisabeth
Pascual, Rosalía
Port, Ariadna
Keywords: Lipofília
Química farmacèutica
Pharmaceutical chemistry
Issue Date: 2014
Publisher: IAPC Publishing
Abstract: The iridium‐catalyzed asymmetric hydrogenation of several N‐sulfonyl allyl amines is reported. All substrates can be easily obtained by the Ir‐catalyzed isomerization of N‐tosylaziridines reported previously. The commercially available threonine‐derived phosphinite (UbaPHOX) iridium complex has been found to be the best catalyst for this catalytic application, affording β‐methyl amines with good to excellent ee values (up to 94%). The synthetic potential of this novel methodology was demonstrated by the formal synthesis of Lorcaserin and LY‐404187.
Note: Reproducció del document publicat a:
It is part of: ADMET & DMPK, 2014, vol. 2, num. 2, p. 107-114
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ISSN: 1848-7718
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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