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Title: Reduced plasma Orexin-A concentrations are associated with cognitive deficits in anorexia nervosa
Author: Steward, Trevor
Mestre-Bach, Gemma
Granero, Roser
Sánchez Zaplana, Isabel
Riesco, Nadine
Vintró Alcaraz, Cristina
Sauchelli, Sarah
Jiménez-Murcia, Susana
Agüera, Zaida
Fernández García, José C.
Garrido-Sanchez, Lourdes
Tinahones, Francisco J.
Casanueva, Felipe F.
Baños Rivera, Rosa María
Botella Arbona, Cristina
Crujeiras, Ana B.
Torre Fornell, Rafael de la
Fernández-Real Lemos, José Manuel
Frühbeck, Gema
Ortega González, Fco. Javier
Rodríguez, Amaia
Menchón Magriñá, José Manuel
Fernández Aranda, Fernando
Keywords: Plasma (Gasos ionitzats)
Trastorns de la cognició
Anorèxia nerviosa
Plasma (Ionized gases)
Cognition disorders
Anorexia nervosa
Issue Date: 27-May-2019
Publisher: Nature Publishing Group
Abstract: Orexins/hypocretins are neuropeptides implicated in numerous processes, including food intake and cognition. The role of these peptides in the psychopathology of anorexia nervosa (AN) remains poorly understood. The aim of the current study was to evaluate the associations between plasma orexin-A (OXA) concentrations and neuropsychological functioning in adult women with AN, and a matched control group. Fasting plasma OXA concentrations were taken in 51 females with AN and in 51 matched healthy controls. Set-shifting was assessed using the Wisconsin Card Sorting Test (WCST), whereas decision making was measured using the Iowa Gambling Task (IGT). The AN group exhibited lower plasma OXA levels than the HC group. Lower mean scores were obtained on the IGT in AN patients. WCST perseverative errors were significantly higher in the AN group compared to HC. In both the AN and HC group, OXA levels were negatively correlated with WCST non-perseverative errors. Reduced plasma OXA concentrations were found to be associated with set-shifting impairments in AN. Taking into consideration the function of orexins in promoting arousal and cognitive flexibility, future studies should explore whether orexin partly underpins the cognitive impairments found in AN.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2019, vol. 9, num. 1, p. 7910
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)

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