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http://hdl.handle.net/2445/145319
Title: | Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia |
Author: | Cillóniz, Catia Dominedò, Cristina Ielpo, Antonella Ferrer Monreal, Miquel Gabarrús, Albert Battaglini, Denise Bermejo Martín, Jesús Meli, Andrea Garcia Vidal, Carolina Liapikou, Adamantia Singer, Mervyn Torres Martí, Antoni |
Keywords: | Pneumònia adquirida a la comunitat Septicèmia Persones grans Community-acquired pneumonia Septicemia Older people |
Issue Date: | 2-Jul-2019 |
Publisher: | MDPI |
Abstract: | Little is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). Methods: We conducted a retrospective observational study of data prospectively collected at the Hospital Clinic of Barcelona over a 13-year period. Consecutive patients hospitalized with CAP were included if they were very old (≥80 years) and divided into those with and without sepsis for comparison. Sepsis was diagnosed based on the Sepsis-3 criteria. The main clinical outcome was 30-day mortality. Results: Among the 4219 patients hospitalized with CAP during the study period, 1238 (29%) were very old. The prevalence of sepsis in this age group was 71%. Male sex, chronic renal disease, and diabetes mellitus were independent risk factors for sepsis, while antibiotic therapy before admission was independently associated with a lower risk of sepsis. Thirty-day and intensive care unit (ICU) mortality did not differ between patients with and without sepsis. In CAP-sepsis group, chronic renal disease and neurological disease were independent risk factors for 30-day mortality. Conclusion: In very old patients hospitalized with CAP, in-hospital and 1-year mortality rates were increased if they developed sepsis. Antibiotic therapy before hospital admission was associated with a lower risk of sepsis. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm8070961 |
It is part of: | Journal of Clinical Medicine, 2019, vol. 8, num. 7 |
URI: | http://hdl.handle.net/2445/145319 |
Related resource: | https://doi.org/10.3390/jcm8070961 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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