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http://hdl.handle.net/2445/145339
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DC Field | Value | Language |
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dc.contributor.author | Cillóniz, Catia | - |
dc.contributor.author | Gabarrús, Albert | - |
dc.contributor.author | Ferrer Monreal, Miquel | - |
dc.contributor.author | Puig de la Bellacasa, Jordi | - |
dc.contributor.author | Rinaudo, Mariano | - |
dc.contributor.author | Mensa Pueyo, Josep | - |
dc.contributor.author | Niederman, Michael S. | - |
dc.contributor.author | Torres Martí, Antoni | - |
dc.date.accessioned | 2019-11-25T14:43:56Z | - |
dc.date.available | 2019-11-25T14:43:56Z | - |
dc.date.issued | 2016-08-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/145339 | - |
dc.description.abstract | Background: Pseudomonas aeruginosa is not a frequent pathogen in community-acquired pneumonia (CAP). However, in patients with severe CAP, P aeruginosa can be the etiology in 1.8% to 8.3% of patients, with a case-fatality rate of 50% to 100%. We describe the prevalence, clinical characteristics, outcomes, and risk factors associated with CAP resulting from multidrug-resistant (MDR) and non-MDR P aeruginosa. Methods: Prospective observational study of 2,023 consecutive adult patients with CAP with definitive etiology. Results: P aeruginosa was found in 77 (4%) of the 2,023 cases with microbial etiology. In 22 (32%) of the 68 cases of P aeruginosa with antibiogram data, the isolates were MDR. Inappropriate therapy was present in 49 (64%) cases of P aeruginosa CAP, including 17/22 (77%) cases of MDR P aeruginosa CAP. Male sex, chronic respiratory disease, C-reactive protein <12.35 mg/dL, and pneumonia severity index risk class IV to V were independently associated with P aeruginosa CAP. Prior antibiotic treatment was more frequent in MDR P aeruginosa CAP compared with non-MDR P aeruginosa (58% vs 29%, P = .029), and was the only risk factor associated with CAP resulting from MDR P aeruginosa. In the multivariate analysis, age ≥65 years, CAP resulting from P aeruginosa, chronic liver disease, neurologic disease, nursing home, criteria of ARDS, acute renal failure, ICU admission, and inappropriate empiric treatment were the factors associated with 30-day mortality. Conclusions: P aeruginosa is an individual risk factor associated with mortality in CAP. The risk factors described can help clinicians to suspect P aeruginosa and MDR P aeruginosa. | ca |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | Elsevier | ca |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.chest.2016.03.042 | - |
dc.relation.ispartof | CHEST Journal, 2016, vol. 150, num. 2, p. 415-425 | - |
dc.relation.uri | https://doi.org/10.1016/j.chest.2016.03.042 | - |
dc.rights | cc by-nc-nd (c) Elsevier, 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | - |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Pseudomonas | - |
dc.subject.classification | Pneumònia adquirida a la comunitat | - |
dc.subject.classification | Resistència als medicaments | - |
dc.subject.other | Community-acquired pneumonia | - |
dc.subject.other | Drug resistance | - |
dc.title | Community-Acquired Pneumonia Due to Multidrug- and Non–Multidrug-Resistant Pseudomonas aeruginosa | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2019-10-31T19:07:03Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
dc.identifier.idimarina | 2569286 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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