Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/145480
Title: Advanced Formulation Approaches for Ocular Drug Delivery: State-Of-The-Art and Recent Patents
Author: Souto, Eliana B.
Dias-Ferreira, João
López-Machado, Ana
Ettcheto Arriola, Miren
Cano Fernández, Amanda
Camins Espuny, Antoni
Espina García, Marta
García, Maria Luisa
Sánchez-López, E. (Elena)
Keywords: Administració de medicaments
Sistemes d'alliberament de medicaments
Farmacologia ocular
Administration of drugs
Drug delivery systems
Ocular pharmacology
Issue Date: 6-Sep-2019
Publisher: MDPI
Abstract: The eye presents extensive perspectives and challenges for drug delivery, mainly because of the extraordinary capacity, intrinsic to this path, for drugs to permeate into the main circulatory system and also for the restrictions of the ocular barriers. Depending on the target segment of the eye, anterior or posterior, the specifications are different. The ocular route experienced in the last decades a lot of progresses related with the development of new drugs, improved formulations, specific-designed delivery and even new routes to administer a drug. Concomitantly, new categories ofmaterialsweredevelopedandadaptedtoencapsulatedrugs. Withsuchadvances,amultiplicityof parameters became possible to be optimized as the increase in bioavailability and decreased toxic effects of medicines. Also, the formulations were capable to easily adhere to specific tissues, increase the duration of the therapeutic effect and even target the delivery of the treatment. The ascending of new delivery systems for ocular targeting is a current focus, mainly because of the capacity to extend the normal time during which the drug exerts its therapeutic effect and, so, supplying the patients with a product which gives them fewer side effects, fewer number of applications and even moreeffectiveoutcomestotheirpathologies,surpassingthetraditionally-usedeyedrops. Depending on the systems, some are capable of increasing the duration of the drug action as gels, emulsions, prodrugs,liposomes,andocularinsertswithhydrophilicproperties,improvingtheabsorptionbythe cornea. In parallel, other devices use as a strategy the capacity to sustain the release of the carried drugs by means of erodible and non-erodible matrices. This review discusses the different types of advanced formulations used for ocular delivery of therapeutics presenting the most recent patents according to the clinical applications. Keywords: ocular drug delivery, patents, bioavailability, anterior eye segment, posterior eye segment, targeted drug delivery
Note: Reproducció del document publicat a: https://doi.org/10.3390/pharmaceutics11090460
It is part of: Pharmaceutics, 2019, vol. 11, p. 460
URI: http://hdl.handle.net/2445/145480
Related resource: https://doi.org/10.3390/pharmaceutics11090460
ISSN: 1999-4923
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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