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Title: Hypothalamic Control of Systemic Glucose Homeostasis: The Pancreas Connection
Author: Claret i Carles, Marc
Pozo, Macarena
Keywords: Homeòstasi
Issue Date: 1-Jan-2018
Publisher: Elsevier
Abstract: Maintenance of glucose homeostasis is mandatory for organismal survival. It is accomplished by complex and coordinated interplay between glucose detection mechanisms and multiple effector systems. The brain, in particular homeostatic regions such as the hypothalamus, plays a crucial role in orchestrating such a highly integral response. We review here current understanding of how the hypothalamus senses glucose availability and participates in systemic glucose homeostasis. We provide an update of the relevant signaling pathways and neuronal subsets involved, as well as of the mechanisms modulating metabolic processes in peripheral tissues such as liver, skeletal muscle, fat, and especially the pancreas. We also discuss the relevance of these networks in human biology and prevalent metabolic conditions such as diabetes and obesity.
Note: Versió postprint del document publicat a:
It is part of: Trends in Endocrinology & Metabolism, 2018, vol. 29, num. 8, p. 581-594
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ISSN: 1043-2760
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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