Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/146159
Title: In vitro and in vivo Virulence Potential of the Emergent Species of the Acinetobacter baumannii (Ab) Group
Author: Cosgaya Castro, Clara
Ratia, Carlos
Marí Almirall, Marta
Rubio Toledano, Laia
Higgins, Paul G.
Seifert, Harald
Roca Subirà, Ignasi
Vila Estapé, Jordi
Keywords: Bacteris gramnegatius
Resistència als medicaments
Gram-negative bacteria
Drug resistance
Issue Date: 24-Oct-2019
Publisher: Frontiers Media
Abstract: The increased use of molecular identification methods and mass spectrometry has revealed that Acinetobacter spp. of the A. baumannii (Ab) group other than A. baumannii are increasingly being recovered from human samples and may pose a health challenge if neglected. In this study 76 isolates of 5 species within the Ab group (A. baumannii n = 16, A. lactucae n = 12, A. nosocomialis n = 16, A. pittii n = 20, and A. seifertii n = 12), were compared in terms of antimicrobial susceptibility, carriage of intrinsic resistance genes, biofilm formation, and the ability to kill Caenorhabditis elegans in an infection assay. In agreement with previous studies, antimicrobial resistance was common among A. baumannii while all other species were generally more susceptible. Carriage of genes encoding different efflux pumps was frequent in all species and the presence of intrinsic class D β-lactamases was reported in A. baumannii, A. lactucae (heterotypic synonym of A. dijkshoorniae) and A. pittii but not in A. nosocomialis and A. seifertii. A. baumannii and A. nosocomialis presented weaker pathogenicity in our in vitro and in vivo models than A. seifertii, A. pittii and, especially, A. lactucae. Isolates from the former species showed decreased biofilm formation and required a longer time to kill C. elegans nematodes. These results suggest relevant differences in terms of antibiotic susceptibility patterns among the members of the Ab group as well as highlight a higher pathogenicity potential for the emerging species of the group in this particular model. Nevertheless, the impact of such potential in the human host still remains to be determined.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3389/fmicb.2019.02429
It is part of: Frontiers in Microbiology, 2019, vol. 10
URI: http://hdl.handle.net/2445/146159
Related resource: http://dx.doi.org/10.3389/fmicb.2019.02429
ISSN: 1664-302X
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Fonaments Clínics)

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