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http://hdl.handle.net/2445/146501
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DC Field | Value | Language |
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dc.contributor.author | Agod, Zsofia | - |
dc.contributor.author | Pazmandi, Kitti | - |
dc.contributor.author | Bencze, Dóra | - |
dc.contributor.author | Vereb, Gyorgy | - |
dc.contributor.author | Biro, Tamas | - |
dc.contributor.author | Szabo, Attila | - |
dc.contributor.author | Rajnavolgyi, Eva | - |
dc.contributor.author | Bacsi, Attila | - |
dc.contributor.author | Engel Rocamora, Pablo | - |
dc.contributor.author | Lanyi, Arpad | - |
dc.date.accessioned | 2019-12-11T13:37:23Z | - |
dc.date.available | 2019-12-11T13:37:23Z | - |
dc.date.issued | 2018-01-26 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/2445/146501 | - |
dc.description.abstract | Signaling lymphocyte activation molecule family (SLAMF) receptors are essential regulators of innate and adaptive immune responses. The function of SLAMF5/CD84, a family member with almost ubiquitous expression within the hematopoietic lineage is poorly defined. In this article, we provide evidence that in human monocyte-derived dendritic cells (moDCs) SLAMF5 increases autophagy, a degradative pathway, which is highly active in dendritic cells (DCs) and plays a critical role in orchestration of the immune response. While investigating the underlying mechanism, we found that SLAMF5 inhibited proteolytic degradation of interferon regulatory factor 8 (IRF8) a master regulator of the autophagy process by a mechanism dependent on the E3-ubiquitin ligase tripartite motif-containing protein 21 (TRIM21). Furthermore, we demonstrate that SLAMF5 influences the ratio of CD1a+ cells in differentiating DCs and partakes in the regulation of IL-1β, IL-23, and IL-12 production in LPS/IFNγ-activated moDCs in a manner that is consistent with its effect on IRF8 stability. In summary, our experiments identified SLAMF5 as a novel cell surface receptor modulator of autophagy and revealed an unexpected link between the SLAMF and IRF8 signaling pathways, both implicated in multiple human pathologies. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2018.00062 | - |
dc.relation.ispartof | Frontiers in Immunology, 2018, vol. 9, p. 62 | - |
dc.relation.uri | https://doi.org/10.3389/fimmu.2018.00062 | - |
dc.rights | cc-by (c) Agod, Zsofia et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Citoquines | - |
dc.subject.classification | Autofàgia | - |
dc.subject.classification | Cèl·lules dendrítiques | - |
dc.subject.other | Cytokines | - |
dc.subject.other | Autophagy | - |
dc.subject.other | Dendritic cells | - |
dc.title | SLAMF5 enhances autophagy and fine-tunes cytokine response in monocyte-derived dendritic cells via stabilization of Interferon regulatory Factor 8 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 686402 | - |
dc.date.updated | 2019-12-11T13:37:24Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29434592 | - |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
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686402.pdf | 1.77 MB | Adobe PDF | View/Open |
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