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http://hdl.handle.net/2445/148000
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DC Field | Value | Language |
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dc.contributor.author | Portella, Guillem | - |
dc.contributor.author | Battistini, Federica | - |
dc.contributor.author | Orozco López, Modesto | - |
dc.date.accessioned | 2020-01-16T11:54:56Z | - |
dc.date.available | 2020-01-16T11:54:56Z | - |
dc.date.issued | 2013-11-21 | - |
dc.identifier.issn | 1553-734X | - |
dc.identifier.uri | http://hdl.handle.net/2445/148000 | - |
dc.description.abstract | Cytosine methylation is one of the most important epigenetic marks that regulate the process of gene expression. Here, we have examined the effect of epigenetic DNA methylation on nucleosomal stability using molecular dynamics simulations and elastic deformation models. We found that methylation of CpG steps destabilizes nucleosomes, especially when these are placed in sites where the DNA minor groove faces the histone core. The larger stiffness of methylated CpG steps is a crucial factor behind the decrease in nucleosome stability. Methylation changes the positioning and phasing of the nucleosomal DNA, altering the accessibility of DNA to regulatory proteins, and accordingly gene functionality. Our theoretical calculations highlight a simple physical-based explanation on the foundations of epigenetic signaling. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pcbi.1003354 | - |
dc.relation.ispartof | PLoS Computational Biology, 2013, vol. 9, num. 11, p. e1003354 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pcbi.1003354 | - |
dc.rights | cc-by (c) Portella, Guillem et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | ADN | - |
dc.subject.classification | Proteïnes | - |
dc.subject.classification | Cèl·lules eucariotes | - |
dc.subject.other | DNA | - |
dc.subject.other | Proteins | - |
dc.subject.other | Eukaryotic cells | - |
dc.title | Understanding the Connetion between Epigenetic DNA Methylation and Nucleosome Positioning from Computer Simulations | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 629980 | - |
dc.date.updated | 2020-01-16T11:54:56Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/291433/EU//SIMDNA | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24278005 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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File | Description | Size | Format | |
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629980.pdf | 2.17 MB | Adobe PDF | View/Open |
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