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Title: TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics
Author: Campo Güerri, Elias
Cymbalista, Florence
Ghia, Paolo
Jäger, Ulrich
Pospisilova, Sarka
Rosenquist, Richard
Schuh, Anna
Stilgenbauer, Stephan
Keywords: Leucèmia limfocítica crònica
Mutació (Biologia)
Pronòstic mèdic
Chronic lymphocytic leukemia
Mutation (Biology)
Issue Date: 15-Nov-2018
Publisher: Ferrata Storti Foundation
Abstract: Chronic lymphocytic leukemia is associated with a highly heterogeneous disease course in terms of clinical outcomes and responses to chemoimmunotherapy. This heterogeneity is partly due to genetic aberrations identified in chronic lymphocytic leukemia cells such as mutations of TP53 and/or deletions in chromosome 17p [del(17p)], resulting in loss of one TP53 allele. These aberrations are associated with markedly decreased survival and predict impaired response to chemoimmunotherapy thus being among the strongest predictive markers guiding treatment decisions in chronic lymphocytic leukemia. Clinical trials demonstrate the importance of accurately testing for TP53 aberrations [both del(17p) and TP53 mutations] before each line of treatment to allow for appropriate treatment decisions that can optimize patient outcomes. The current report reviews the diagnostic methods to better detect TP53 disruption, the role of TP53 aberrations in treatment decisions and current therapies available for patients with chronic lymphocytic leukemia carrying these abnormalities. The standardization in sequencing technologies for accurate identification of TP53 mutations and the importance of continued evaluation of TP53 aberrations throughout initial and subsequent lines of therapy remain unmet clinical needs as new therapeutic alternatives become available
Note: Reproducció del document publicat a:
It is part of: Haematologica, 2018, vol. 103, num. 12, p. 1956-1968
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ISSN: 0390-6078
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Fonaments Clínics)

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