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Title: Adenosine A1-A2A Receptor Heteromer as a Possible Target for Early-Onset Parkinson's Disease
Author: Fernández Dueñas, Víctor
Pérez Arévalo, Andrea
Altafaj, Xavier
Ferré, Sergi
Ciruela Alférez, Francisco
Keywords: Malaltia de Parkinson
Parkinson's disease
Issue Date: 22-Nov-2017
Publisher: Frontiers Media
Abstract: Parkinson's disease (PD) is a progressive, neurodegenerative disorder that affects ~1% of individuals over the age of 60, which turns to 5% in subjects up to 85 years (de Lau and Breteler, 2006). On the other hand, a form of PD, called early-onset PD (EOPD), arises at an earlier age (<45; Bonifati et al., 2005; Ylikotila et al., 2015). EOPD patients generally display a slower progression of the disease and present a better response to dopaminergic treatments; however, they may finally develop a full PD symptomatology (i.e., bradykinesia, resting tremor, muscular rigidity and postural instability, drug-induced dyskinesia; Olgiati et al., 2016).
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It is part of: Frontiers in Neuroscience, 2017, vol. 11, num. 652
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ISSN: 1662-4548
Appears in Collections:Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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