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http://hdl.handle.net/2445/148044
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DC Field | Value | Language |
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dc.contributor.author | Baliakas, Panagiotis | - |
dc.contributor.author | Moysiadis, Theodoros | - |
dc.contributor.author | Hadzidimitriou, Anastasia | - |
dc.contributor.author | Xochelli, Aliki | - |
dc.contributor.author | Jeromin, Sabine | - |
dc.contributor.author | Agathangelidis, Andreas | - |
dc.contributor.author | Mattsson, Mattias | - |
dc.contributor.author | Sutton, Lesley-Ann | - |
dc.contributor.author | Minga, Eva | - |
dc.contributor.author | Scarfò, Lydia | - |
dc.contributor.author | Rossi, Davide | - |
dc.contributor.author | Davis, Zadie | - |
dc.contributor.author | Villamor i Casas, Neus | - |
dc.contributor.author | Parker, Helen | - |
dc.contributor.author | Kotaskova, Jana | - |
dc.contributor.author | Stalika, Evangelia | - |
dc.contributor.author | Plevova, Karla | - |
dc.contributor.author | Mansouri, Larry | - |
dc.contributor.author | Cortese, Diego | - |
dc.contributor.author | Navarro López, Alba | - |
dc.contributor.author | Delgado, Julio (Delgado González) | - |
dc.contributor.author | Larrayoz, Marta | - |
dc.contributor.author | Young, Emma | - |
dc.contributor.author | Anagnostopoulos, Achilles | - |
dc.contributor.author | Smedby, Karin E. | - |
dc.contributor.author | Juliusson, Gunnar | - |
dc.contributor.author | Sheehy, Oonagh | - |
dc.contributor.author | Catherwood, Mark | - |
dc.contributor.author | Strefford, Jonathan C. | - |
dc.contributor.author | Stavroyianni, Niki | - |
dc.contributor.author | Belessi, Chrysoula | - |
dc.contributor.author | Pospisilova, Sarka | - |
dc.contributor.author | Oscier, David | - |
dc.contributor.author | Gaidano, Gianluca | - |
dc.contributor.author | Campo Güerri, Elias | - |
dc.contributor.author | Haferlach, Claudia | - |
dc.contributor.author | Ghia, Paolo | - |
dc.contributor.author | Rosenquist, Richard | - |
dc.contributor.author | Stamatopoulos, Kostas | - |
dc.date.accessioned | 2020-01-16T14:47:22Z | - |
dc.date.available | 2020-01-16T14:47:22Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 0390-6078 | - |
dc.identifier.uri | http://hdl.handle.net/2445/148044 | - |
dc.description.abstract | Chronic lymphocytic leukemia (CLL) patients with differentialsomatic hypermutation status of the immunoglobulin heavy vari-able genes, namely mutated or unmutated, display fundamentalclinico-biological differences. Considering this, we assessed prognosisseparately within mutated (M-CLL) and unmutated (U-CLL) CLL in 3015patients, hypothesizing that the relative significance of relevant indica-tors may differ between these two categories. Within Binet A M-CLLpatients, besides TP53abnormalities, trisomy 12 and stereotyped subset#2 membership were equivalently associated with the shortest time-to-first-treatment and a treatment probability at five and ten years afterdiagnosis of 40% and 55%, respectively; the remaining cases exhibited5-year and 10-year treatment probability of 12% and 25%, respectively.Within Binet A U-CLL patients, besides TP53abnormalities, del(11q)and/or SF3B1mutations were associated with the shortest time-to-first-treatment (5- and 10-year treatment probability: 78% and 98%, respec-tively); in the remaining cases, males had a significantly worse prognosisthan females. In conclusion, the relative weight of indicators that canaccurately risk stratify early-stage CLL patients differs depending on thesomatic hypermutation status of the immunoglobulin heavy variablegenes of each patient. This finding highlights the fact that compartmen-talized approaches based on immunogenetic features are necessary torefine and tailor prognostication in CLL. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Ferrata Storti Foundation | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3324/haematol.2018.195032 | - |
dc.relation.ispartof | Haematologica, 2019, vol. 104, num. 2, p. 360-369 | - |
dc.relation.uri | https://doi.org/10.3324/haematol.2018.195032 | - |
dc.rights | (c) Ferrata Storti Foundation, 2018 | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Leucèmia limfocítica crònica | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.other | Chronic lymphocytic leukemia | - |
dc.subject.other | Prognosis | - |
dc.title | Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 682535 | - |
dc.date.updated | 2020-01-16T14:47:22Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/692298/EU//MEDGENET | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 4213867 | - |
dc.identifier.pmid | 30262567 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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682535.pdf | 1.32 MB | Adobe PDF | View/Open |
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