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http://hdl.handle.net/2445/148127
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DC Field | Value | Language |
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dc.contributor.author | Pacchiarotti, Isabella | - |
dc.contributor.author | Tiihonen, Jari | - |
dc.contributor.author | Kotzalidis, Georgios D. | - |
dc.contributor.author | Verdolini, Norma | - |
dc.contributor.author | Murru, Andrea | - |
dc.contributor.author | Goikolea, José Manuel | - |
dc.contributor.author | Valentí Ribas, Marc | - |
dc.contributor.author | Aedo, Alberto | - |
dc.contributor.author | Vieta i Pascual, Eduard, 1963- | - |
dc.date.accessioned | 2020-01-17T15:35:25Z | - |
dc.date.available | 2020-02-12T06:10:20Z | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 0924-977X | - |
dc.identifier.uri | http://hdl.handle.net/2445/148127 | - |
dc.description.abstract | Long-Acting Injectable Antipsychotics (LAIs) are used to overcome non-compliance in psychoses, mainly schizophrenia spectrum disorders. We aimed to summarize available evidence of studies comparing the efficacy of LAIs to placebo or oral medications for Bipolar Disorder (BD) and/or Schizoaffective Disorder (SAD). We searched six databases from inception to 28-March-2018, using the strategy: long-acting antipsychotics AND (bipolar disorder OR schizoaffective disorder OR mania OR manic OR bipolar depression). We included peer-reviewed double-blind comparisons of LAIs for any clinical outcome occurrence in BD, or open mirror studies with same prospective as retrospective assessment periods. We excluded studies reporting on mixed schizophrenia/SAD populations without reporting results separately. The pooled records amounted to 642. After duplicate removal and inclusion/exclusion criteria application, we included 15 studies, 6 double-blind and 9 open, 13 assessing BD and 2 SAD. Depot neuroleptics prevented manic, but not depressive recurrences and may worsen depressive symptoms. Risperidone long-acting injectable was found to be effective in protecting from any mood/manic symptom compared to placebo, but not from depressive recurrences. Add-on or monotherapy paliperidone palmitate in SAD patients protected from psychotic, depressive, and manic symptoms. In patients with BD-I with a manic episode at study enrolment, aripiprazole monohydrate significantly delayed time to recurrence of manic episodes without inducing depressive episodes. LAIs are effective and well-tolerated maintenance treatments for BD and SAD. They showed better efficacy in preventing mania than depression. LAIs may be first-line for BD-I and SAD patients with a manic predominant polarity and with non-adherence problems. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.euroneuro.2019.02.003 | - |
dc.relation.ispartof | European Neuropsychopharmacology, 2019, vol. 29, num. 4, p. 457-470 | - |
dc.relation.uri | https://doi.org/10.1016/j.euroneuro.2019.02.003 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Antipsicòtics | - |
dc.subject.classification | Trastorn bipolar | - |
dc.subject.classification | Esquizofrènia | - |
dc.subject.other | Antipsychotic drugs | - |
dc.subject.other | Manic-depressive illness | - |
dc.subject.other | Schizophrenia | - |
dc.title | Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 685977 | - |
dc.date.updated | 2020-01-17T15:35:26Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 4207789 | - |
dc.identifier.pmid | 30770235 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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