Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/148840
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Salvatella i Giralt, Xavier | - |
dc.contributor.author | Szulc, Elzbieta Maria | - |
dc.contributor.other | Universitat de Barcelona. Facultat de Farmàcia | - |
dc.date.accessioned | 2020-01-28T12:12:56Z | - |
dc.date.available | 2022-01-09T06:10:17Z | - |
dc.date.issued | 2020-01-09 | - |
dc.identifier.uri | http://hdl.handle.net/2445/148840 | - |
dc.description.abstract | [eng] Androgen receptor is a transcription factor that plays a key role in prostate cancer development and progression. Its N-terminal intrinsically disordered activation domain is an example of ill- structured negatively charged "acid blob" or "negative noodle" described in 1988 by Paul B. Sigler. In his model the transcription pre-initiation complex formation relies on non-specific interactions between the "negative noodles" of the transcriptional activating proteins and hydroxyl groups of the heptapeptide repeats of the C-terminal domain in the largest subunit of RNA polymerase II. Here, we take advantage of various biophysical methods to understand the AR activation domain characteristics, its ability to undergo liquid-liquid phase separation and the importance of both for protein-protein interactions of the domain. We show relevance of the secondary structure elements in the AD function despite its general "acid blob" character. | - |
dc.format.extent | 223 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Universitat de Barcelona | - |
dc.rights | (c) Szulc, 2020 | - |
dc.source | Tesis Doctorals - Facultat - Farmàcia i Ciències de l'Alimentació | - |
dc.subject.classification | Factors de transcripció | - |
dc.subject.classification | Càncer de pròstata | - |
dc.subject.classification | Andrògens | - |
dc.subject.classification | Proteïnes | - |
dc.subject.other | Transcription factors | - |
dc.subject.other | Prostate cancer | - |
dc.subject.other | Androgens | - |
dc.subject.other | Proteins | - |
dc.title | Structural insights into “acid blobs and negative noodles” – The androgen receptor as a case study | - |
dc.type | info:eu-repo/semantics/doctoralThesis | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2020-01-28T12:12:56Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.tdx | http://hdl.handle.net/10803/668406 | - |
Appears in Collections: | Tesis Doctorals - Facultat - Farmàcia i Ciències de l'Alimentació |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
EMS_PhD_THESIS.pdf | 14.08 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.