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DC Field | Value | Language |
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dc.contributor.author | García-Otero, Laura | - |
dc.contributor.author | López, Marta | - |
dc.contributor.author | Guitart Mampel, Mariona | - |
dc.contributor.author | Morén Núñez, Constanza | - |
dc.contributor.author | Goncé Mellgren, Anna | - |
dc.contributor.author | Esteve, Carol | - |
dc.contributor.author | Salazar, Laura | - |
dc.contributor.author | Gómez, Olga | - |
dc.contributor.author | Martínez Crespo, Josep M. (Josep Maria) | - |
dc.contributor.author | Torres, Berta | - |
dc.contributor.author | César, Sergi | - |
dc.contributor.author | Garrabou Tornos, Glòria | - |
dc.contributor.author | Crispi Brillas, Fàtima | - |
dc.contributor.author | Gratacós Solsona, Eduard | - |
dc.date.accessioned | 2020-01-29T16:27:44Z | - |
dc.date.available | 2020-01-29T16:27:44Z | - |
dc.date.issued | 2019-03-04 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/148934 | - |
dc.description | Podeu consultar les dades crues associades a aquest article a: http://hdl.handle.net/2445/128304 [recurs relacionat] | - |
dc.description.abstract | BACKGROUND: Mitochondrial toxicity related to maternal combined antiretroviral treatment (cART) may have an impact on the heart of HIV-exposed uninfected (HEU) fetuses. Our objective was to evaluate fetal cardiovascular and mitochondrial biomarkers in HIV pregnancies. METHODS: Prospective cohort including 47 HIV-infected and 47 non HIV-infected pregnancies. Fetal echocardiography was performed at 26-32 weeks of pregnancy. Umbilical cord blood and placental tissue were collected to study mitochondrial DNA content (mtDNA) (ratio 12SrRNA/RNAseP) and mitochondrial function (cytochrome c oxidase, COX, enzymatic activity) normalized by mitochondrial content (citrate synthase, CS). RESULTS: HEU fetuses showed hypertrophic hearts (left myocardial wall thickness: HIV mean 3.21 mm (SD 0.81) vs. non-HIV 2.72 (0.42), p = 0.012), with signs of systolic and diastolic dysfunction (isovolumic relaxation time: HIV 52.2 ms (8.85) vs. non-HIV 42.5 ms (7.30); p<0.001). Cord blood mitochondrial content was significantly increased in HIV-exposed fetuses (CS activity: HIV 82.9 nmol/min.mg of protein (SD 40.5) vs. non-HIV 56.7 nmol/min.mg of protein (28.4); p = 0.007), with no differences in mtDNA content and COX activity. Both myocardial and mitochondrial mass parameters were significantly associated with zidovudine exposure. CONCLUSIONS: HEU fetuses showed signs of increased myocardial and mitochondrial mass associated with maternal zidovudine treatment, suggesting a fetal adaptive response to cART toxicity. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0213279 | - |
dc.relation.ispartof | PLoS One, 2019, vol. 14, num. 3, p. e0213279 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0213279 | - |
dc.relation.uri | http://hdl.handle.net/2445/128304 | - |
dc.rights | cc-by (c) García-Otero, Laura et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Fetus | - |
dc.subject.classification | Antiretrovirals | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.other | Fetus | - |
dc.subject.other | Antiretroviral agents | - |
dc.subject.other | HIV (Viruses) | - |
dc.title | Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 690434 | - |
dc.date.updated | 2020-01-29T16:27:44Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30830946 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
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