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Title: Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
Author: Obón Santacana, Mireia
Kaaks, Rudolf
Slimani, Nadia
Luján Barroso, Leila
Freisling, Heinz
Ferrari, Pietro
Dossus, Laure
Chabbert-Buffet, Nathalie
Baglietto, Laura
Fortner, Renée T.
Boeing, Heiner
Tjønneland, Anne
Olsen, Anja
Overvad, Kim
Menéndez, Virginia
Molina Montes, Esther
Larrañaga, Nerea
Chirlaque, María Dolores
Ardanaz, Eva
Khaw, Kay-Tee
Wareham, Nicholas J.
Travis, Ruth C.
Lu, Yunxia
Merritt, Melissa A.
Trichopoulou, Antonia
Benetou, Vassiliki
Trichopoulos, Dimitrios
Saieva, Calogero
Sieri, Sabina
Tumino, Rosario
Sacerdote, Carlotta
Galasso, Rocco
Bueno de Mesquita, H. Bas
Wirfält, Elisabet
Ericson, Ulrika
Idahl, Annika
Ohlson, Nina
Skeie, Guri
Gram, Inger T.
Weiderpass, Elisabete
Keywords: Efectes secundaris
Trastorns de la conducta alimentària
Càncer d'endometri
Side effects
Eating disorders
Endometrial cancer
Issue Date: 26-Aug-2014
Publisher: Cancer Research UK
Abstract: Background: three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk. Methods: cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method. Results: no associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203). Conclusions: dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.
Note: Versió postprint del document publicat a:
It is part of: British Journal of Cancer, 2014, vol. 111, num. 5, p. 987-997
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ISSN: 0007-0920
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)

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