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Title: | Circulating sex hormone binding globulin: an integrating biomarker for an adverse cardio-metabolic profile in obese pregnant women |
Author: | Xargay i Torrent, Sílvia Carreras Badosa, Gemma Prats Puig, Anna Soriano, Pilar Álvarez Castaño, Elena Ferri, María José Borrat Padrosa, Sara Zegher, Francis de Ibáñez Toda, Lourdes López Bermejo, Abel Bassols, Judit |
Keywords: | Hormones sexuals Marcadors bioquímics Embarassades Cardiologia Obesitat Sex hormones Biochemical markers Pregnant women Cardiology Obesity |
Issue Date: | 15-Oct-2018 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Sex hormone-binding globulin (SHBG) negatively associates with pre-gestational body mass index (BMI) and gestational weight gain. The link with other cardio-metabolic risk factors in pregnant women is poorly understood. Our aim was to study the association of SHBG levels with common cardio-metabolic risk parameters in pregnant woman. Serum SHBG was quantified in 291 Caucasian pregnant women (142 with normal weight, 42 with pregestational obesity, 50 with gestational obesity and 57 with pregestational plus gestational obesity) with uncomplicated pregnancies and parturition. Cardio-metabolic [C-reactive protein (CRP), blood pressure (BP), glycosylated hemoglobin (HbAc1), glucose, C-peptide, insulin, triglycerides and high molecular weight (HMW) adiponectin], and endocrine [testosterone and estradiol] parameters were also assessed. SHBG was negatively correlated with BMI, but also with CRP, BP, HbAc1, pre and post-load glucose, C-peptide, HOMA-IR, triglycerides; and positively with HMW adiponectin (all p<0.01 to p<0.0001). These associations were more robust in women with pregestational plus gestational obesity, who had lower SHBG, in comparison to normal-weight women (p<0.0001). In multivariate analyses in women with pregestational plus gestational obesity SHBG showed independent associations with CRP (β = -0.352, p = 0.03, R2 = 8.0%), DBP (β = -0.353, p = 0.03, R2 = 7.0%) and SBP (β = -0.333, p = 0.04, R2 = 6.0%) independently of BMI and metabolic and endocrine parameters. SHBG is decreased in pregnant women with pregestational plus gestational obesity in association with common cardio-metabolic parameters. SHBG could represent an integrating biomarker for an adverse cardio-metabolic profile in pregnant women with pregestational plus gestational obesity. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0205592 |
It is part of: | PLoS One, 2018, vol. 13, num. 10, p. e0205592 |
URI: | http://hdl.handle.net/2445/149137 |
Related resource: | https://doi.org/10.1371/journal.pone.0205592 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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