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http://hdl.handle.net/2445/149342
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DC Field | Value | Language |
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dc.contributor.author | Valenzuela Alcaraz, Brenda I. | - |
dc.contributor.author | Serafin, Anna M. | - |
dc.contributor.author | Sepúlveda Martínez, Álvaro | - |
dc.contributor.author | Casals Soler, Gemma | - |
dc.contributor.author | Rodríguez López, Mérida | - |
dc.contributor.author | Garcia Otero, Laura | - |
dc.contributor.author | Cruz Lemini, Mónica Cristina | - |
dc.contributor.author | Bijnens, Bart | - |
dc.contributor.author | Sitges Carreño, Marta | - |
dc.contributor.author | Balasch Cortina, Juan | - |
dc.contributor.author | Gratacós Solsona, Eduard | - |
dc.contributor.author | Crispi Brillas, Fàtima | - |
dc.date.accessioned | 2020-02-04T09:30:24Z | - |
dc.date.available | 2020-02-04T09:30:24Z | - |
dc.date.issued | 2018-06-13 | - |
dc.identifier.issn | 1470-0328 | - |
dc.identifier.uri | http://hdl.handle.net/2445/149342 | - |
dc.description.abstract | OBJECTIVE: To assess the postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductive technologies (ART) in children at 3 years of age. DESIGN: A cohort study of children conceived by ART. SETTING: Maternal-Fetal Medicine Unit, Hospital Clinic Barcelona, Spain. POPULATION SAMPLE: Eighty singleton pregnancies conceived by ART and 80 spontaneously conceived (controls) followed from fetal life up to childhood. METHODS: Cardiovascular evaluation was performed at 3 years of corrected age, including echocardiography, carotid intima-media (cIMT) by ultrasound, and blood pressure. MAIN OUTCOME MEASURES: Postnatal persistence of cardiovascular changes in children conceived by ART. RESULTS: Compared with controls, children conceived by ART showed larger atria (right atrial area: control 4.9 cm2 (0.9) versus ART 5.5 cm2 (0.9), P < 0.001), more globular ventricles (right ventricular sphericity index: control mean 1.8 (SD 0.5) versus ART 1.6 (0.2), P < 0.001), and signs of systolic (tricuspid annular plane systolic excursion: control 18 mm (2) versus ART 16 mm (3), P < 0.001) and diastolic dysfunction (isovolumic relaxation time: control 68 ms (12) versus ART 79 ms (12), P < 0.001). ART children also presented increased systolic blood pressure (control 90 mmHg (6) versus ART 94 mmHg (5), P < 0.003) and cIMT (control 0.52 μm (0.14) versus ART 0.60 μm (0.16), P < 0.001) as compared with those spontaneously conceived. CONCLUSIONS: Cardiovascular changes previously reported in ART fetuses persist postnatally at 3 years of age. These results underscore the importance of future studies for assessing the long-term cardiovascular health associated with ART. TWEETABLE ABSTRACT: Cardiovascular changes described in fetuses conceived by ART, persist in children at 3 years of age. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | John Wiley & Sons | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1111/1471-0528.15246 | - |
dc.relation.ispartof | BJOG: An International Journal of Obstetrics and Gynaecology, 2018, vol. 126, num. 2, p. 291-298 | - |
dc.relation.uri | https://doi.org/10.1111/1471-0528.15246 | - |
dc.rights | (c) John Wiley & Sons, 2018 | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Reproducció assistida | - |
dc.subject.classification | Control de la natalitat | - |
dc.subject.other | Reproductive technology | - |
dc.subject.other | Birth control | - |
dc.title | Postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductivetechnologies: a cohort study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 690435 | - |
dc.date.updated | 2020-02-04T09:30:24Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) |
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File | Description | Size | Format | |
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690435.pdf | 263.88 kB | Adobe PDF | View/Open |
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