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Title: Role of c-Jun N-Terminal Kinases (JNKs) in Epilepsy and Metabolic Cognitive Impairment
Author: Busquets Figueras, Oriol
Ettcheto Arriola, Miren
Cano Fernández, Amanda
Manzine, Patricia
Sánchez-López, E. (Elena)
Espinosa-Jiménez, Triana
Verdaguer Cardona, Ester
Castro-Torres, Rubén Darío
Beas Zárate, Carlos
Sureda, Francesc X.
Olloquequi, Jordi
Auladell i Costa, M. Carme
Folch, Jaume
Camins Espuny, Antoni
Keywords: Cervell
Diabetis no-insulinodependent
Non-insulin-dependent diabetes
Issue Date: 30-Dec-2019
Publisher: MDPI
Abstract: Previous studies have reported that the regulatory function of the different c-Jun N-terminal kinases isoforms (JNK1, JNK2, and JNK3) play an essential role in neurological disorders, such as epilepsy and metabolic-cognitive alterations. Accordingly, JNKs have emerged as suitable therapeutic strategies. In fact, it has been demonstrated that some unspecific JNK inhibitors exert antidiabetic and neuroprotective effects, albeit they usually show high toxicity or lack therapeutic value. In this sense, natural specific JNK inhibitors, such as Licochalcone A, are promising candidates. Nonetheless, research on the understanding of the role of each of the JNKs remains mandatory in order to progress on the identification of new selective JNK isoform inhibitors. In the present review, a summary on the current gathered data on the role of JNKs in pathology is presented, as well as a discussion on their potential role in pathologies like epilepsy and metabolic-cognitive injury. Moreover, data on the effects of synthetic small molecule inhibitors that modulate JNK-dependent pathways in the brain and peripheral tissues is reviewed.
Note: Reproducció del document publicat a:
It is part of: International Journal of Molecular Sciences, 2019, vol. 21, num. 1, p. 255
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ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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