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Title: Effect of Different Skin Penetration Promoters in Halobetasol Propionate Permeation and Retention in Human Skin
Author: Carvajal-Vidal, Paulina
Mallandrich Miret, Mireia
García López, María Luisa
Calpena Campmany, Ana Cristina
Keywords: Dermatitis
Adrenocortical hormones
Issue Date: 21-Nov-2017
Publisher: MDPI
Abstract: Halobetasol propionate (HB) is a potent synthetic corticosteroid used against inflammatory skin diseases, such as dermatitis, eczema, and psoriasis, among others. The aim of this study is to define how the presence of different skin penetration enhancers (nonane, menthone, limonene, azone, carene, decanol, linoleic acid and cetiol) affects the penetration and retention in skin of HB. To determine drug penetration through skin, 5% of each promoter was used in an ex vivo system with human skin on Franz cells. The results showed that the highest permeation occurs in the presence of menthone, followed by nonane. Permeation parameters were determined. The in vivo test was assessed, and the formulation containing HB-menthone presented better anti-inflammatory efficacy. These results are useful to generate a specific treatment according to each patient's needs, and the inflammatory characteristics of the disease. View Full-Text Keywords: halobetasol propionate; permeation enhancers; skin permeation; skin inflammation; topical corticosteroid
Note: Reproducció del document publicat a:
It is part of: International Journal of Molecular Sciences, 2017, vol. 18, num. 11, p. 2475
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ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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