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Title: A critical retrospective and prospective review of designs and materials in in-line solid-phase extraction capillary electrophoresis
Author: Pont Villanueva, Laura
Peró Gascón, Roger
Giménez López, Estela
Sanz Nebot, María Victoria
Benavente Moreno, Fernando J. (Julián)
Keywords: Electroforesi capil·lar
Síntesi en fase sólida
Capillary electrophoresis
Solid-phase synthesis
Issue Date: 2019
Publisher: Elsevier B.V.
Abstract: Several strategies have been developed to decrease the concentration limits of detection (LODs) in capillary electrophoresis (CE). Nowadays, chromatographic-based preconcentration using a microcartridge integrated in the separation capillary for in-line solid-phase extraction capillary electrophoresis (SPE-CE) is one of the best alternatives for high throughput and reproducible sample clean-up and analyte preconcentration. This review covers different designs (geometrical configurations, with frits or fritless, capillary types, compatibility with commercial instrumentation, etc.) and materials (sorbents, supports, affinity ligands, etc.) applied for almost 30 years to prepare in-line SPE-CE microcartridges (i.e. analyte concentrators), with emphasis on the conventional unidirectional configuration in capillary format. Advantages, disadvantages and future perspectives are analyzed in detail to provide the reader a wide overview about the great potential of this technique to enhance sensitivity and address trace analysis.
Note: Versió postprint del document publicat a:
It is part of: Analytica Chimica Acta, 2019, vol. 1079, p. 1-19
ISSN: 0003-2670
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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