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http://hdl.handle.net/2445/151389
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DC Field | Value | Language |
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dc.contributor.author | Benavente Moreno, Fernando J. (Julián) | - |
dc.contributor.author | Peró Gascón, Roger | - |
dc.contributor.author | Pont Villanueva, Laura | - |
dc.contributor.author | Jaumot Soler, Joaquim | - |
dc.contributor.author | Barbosa Torralbo, José | - |
dc.contributor.author | Sanz Nebot, María Victoria | - |
dc.date.accessioned | 2020-02-27T17:24:59Z | - |
dc.date.available | 2020-12-31T06:10:18Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0021-9673 | - |
dc.identifier.uri | http://hdl.handle.net/2445/151389 | - |
dc.description.abstract | We present capillary electrophoresis-mass spectrometry (CE-MS) in combination with advanced chemometric tools for the analysis of bioactive compounds in food, in particular for the identification of antihypertensive peptides in a nutraceutical derived from a bovine milk protein hydrolysate. Different extracts of the nutraceutical were analyzed by CE-MS, and the electropherograms were processed using a novel data analysis workflow that included regions of interest (ROIs) compression and multivariate curve resolution alternating least squares (MCR-ALS). MCR-ALS permitted the description of the nutraceutical extract as ten characteristic components with their electrophoretic profiles and mass spectra. Twenty-two compounds were tentatively identified as antihypertensive bovine casein fragments through a mass search in a database of bioactive peptides. The identity of 17 antihypertensive peptides was reliably confirmed by capillary electrophoresis-tandem mass spectrometry. The proposed analytical approach demonstrated the potential to obtain a characteristic and activity-related fingerprint for quality control and authentication of the antihypertensive nutraceutical. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.chroma.2018.10.018 | - |
dc.relation.ispartof | Journal of Chromatography A, 2018, vol. 1579, p. 129-137 | - |
dc.relation.uri | https://doi.org/10.1016/j.chroma.2018.10.018 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Pèptids | - |
dc.subject.classification | Electroforesi capil·lar | - |
dc.subject.classification | Quimiometria | - |
dc.subject.classification | Espectrometria de masses | - |
dc.subject.other | Peptides | - |
dc.subject.other | Capillary electrophoresis | - |
dc.subject.other | Chemometrics | - |
dc.subject.other | Mass spectrometry | - |
dc.title | Identification of antihypertensive peptides in nutraceuticals by capillary electrophoresis-mass spectrometry | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 676801 | - |
dc.date.updated | 2020-02-27T17:24:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
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676801.pdf | 1.45 MB | Adobe PDF | View/Open |
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