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http://hdl.handle.net/2445/151519
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DC Field | Value | Language |
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dc.contributor.author | Fernández Montolí, Ma. Eulalia | - |
dc.contributor.author | Tous, Sara | - |
dc.contributor.author | Medina, Gonzalo | - |
dc.contributor.author | Castellanau, Marta | - |
dc.contributor.author | García-Tejedor, Amparo | - |
dc.contributor.author | Sanjosé Llongueras, Silvia de | - |
dc.date.accessioned | 2020-02-29T08:43:03Z | - |
dc.date.available | 2020-10-20T05:10:27Z | - |
dc.date.issued | 2019-10-20 | - |
dc.identifier.uri | http://hdl.handle.net/2445/151519 | - |
dc.description.abstract | Objective: To assess the long-term risk factors predicting residual/recurrent cervical intraepithelial neoplasia (CIN 2–3) and time to recurrence after large loop excision of the transformation zone (LLETZ). Design: Retrospective study. Setting: Colposcopy clinic. Population: 242 women with CIN 2–3 treated between 1996 and 2006 and followed up until June 2016. Methods: Age, margins and high risk-human papillomavirus (HR-HPV) were estimated using Cox proportional hazard and unconditional logistic regression models. The cumulative probability of treatment failure was estimated by Kaplan-Meier analysis. Main Outcome measure: Histologically confirmed CIN 2-3, HR-HPV, margins, age. Results: CIN 2-3 was associated with HR-HPV (HR =30.5; 95% CI =3.80-246.20); age >35 years (HR =5.53; 95% CI =1.22-25.13); and margins (HR = 7.31; 95% CI = 1.60–33.44). HR-HPV showed a sensitivity of 88.8% and a specificity of 80%. Ecto(+)/endocervical(+)(16.7%), uncertain (19.4%) and ecto(-)/endocervical(+) margins (9.1%) showed a higher risk of recurrence (OR = 13.20(95% CI =1.02-170.96), 15.84(95% CI =3.02-83.01), and 6.60(95% CI =0.88-49.53)), respectively. Women with involved margins and/or HR-HPV positive had more treatment failure than those who were HR-HPV negative or had clear margins (P-log rank<0.001). Conclusions: HR-HPV and margins seem essential for stratifying post- LLETZ risk, and enable personalised management. Given that clear margins present a lower risk, a large excision may be indicated in older women in order to reduce the risk. Funding statement: This study has received no funding. | ca |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | Wiley | ca |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1111/1471-0528.15996 | - |
dc.relation.ispartof | BJOG: An International Journal of Obstetrics & Gynaecology, 2019, vol. 127, num. 3, p. 377-387 | - |
dc.relation.uri | https://doi.org/10.1111/1471-0528.15996 | - |
dc.rights | (c) Wiley, 2019 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de coll uterí | - |
dc.subject.classification | Malalties de la dona | - |
dc.subject.other | Cervix cancer | - |
dc.subject.other | Women diseases | - |
dc.title | Long‐term predictors of residual or recurrent cervical intraepithelial neoplasia 2‐3 after treatment with a large loop excision of the transformation zone: a retrospective study | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2020-02-22T21:32:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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Fern-ndez-Montol-_et_al-2019-BJOG__An_International_Journal_of_Obstetrics_&_Gynaecology.pdf | 1.49 MB | Adobe PDF | View/Open |
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