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Title: Non-Coding RNAs in Hodgkin Lymphoma.
Author: Cordeiro Santanach, Anna
Monzó Planella, Mariano
Navarro Ponz, Alfons
Keywords: Malaltia de Hodgkin
Hodgkin's disease
Issue Date: 29-May-2017
Publisher: MDPI
Abstract: MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression by binding to the 3'-UTR of their target genes, can act as oncogenes or tumor suppressors. Recently, other types of non-coding RNAs-piwiRNAs and long non-coding RNAs-have also been identified. Hodgkin lymphoma (HL) is a B cell origin disease characterized by the presence of only 1% of tumor cells, known as Hodgkin and Reed-Stenberg (HRS) cells, which interact with the microenvironment to evade apoptosis. Several studies have reported specific miRNA signatures that can differentiate HL lymph nodes from reactive lymph nodes, identify histologic groups within classical HL, and distinguish HRS cells from germinal center B cells. Moreover, some signatures are associated with survival or response to chemotherapy. Most of the miRNAs in the signatures regulate genes related to apoptosis, cell cycle arrest, or signaling pathways. Here we review findings on miRNAs in HL, as well as on other non-coding RNAs.
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It is part of: International Journal of Molecular Sciences, 2017, vol. 18, num. 6, p. 1154
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ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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