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http://hdl.handle.net/2445/151860
Title: | Dupilumab improves patient-reported outcomes in patients with chronic rhinosinusitis with nasal polyps and comorbid asthma |
Author: | Bachert, Claus Hellings, Peter W. Mullol i Miret, Joaquim Naclerio, Robert M. Chao, Jingdong Amin, Nikhil Grabher, Annette Swanson, Brian N. Hamilton, Jennifer D. Guillonneau, Sophie Christine Taniou Zhang, Donghui Pirozzi, Gianluca Graham, Neil M. H. Staudinger, Heribert Mannent, Leda P. Khan, Asif |
Keywords: | Asma Sinusitis Asthma Sinusitis |
Issue Date: | 27-Mar-2019 |
Publisher: | Elsevier |
Abstract: | Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory condition affecting the upper airways, with chronic symptoms such as nasal congestion, partial (hyposmia) or total (anosmia) loss of smell, anterior/posterior rhinorrhea, and mild facial pain.1 As many as 66% of patients with CRSwNP have comorbid asthma and suffer from more severe nasal obstruction, higher levels of lower airway inflammation, and worse asthma control than those without CRS.2, 3 Thus, patients with CRSwNP and comorbid asthma have a high disease burden, seriously impacting health-related quality of life (HRQoL).2, 3 Markers of type 2-mediated inflammation and antibody production (eg, IL-5, IgE) are associated with both CRSwNP and asthma pathogenesis.2 |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.jaip.2019.03.023 |
It is part of: | The Journal of Allergy and Clinical Immunology: In Practice, 2019, vol. 7, num. 7, p. 2447-2449.e2 |
URI: | http://hdl.handle.net/2445/151860 |
Related resource: | https://doi.org/10.1016/j.jaip.2019.03.023 |
ISSN: | 2213-2198 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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