Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/152321
Title: | Clinical presentation of young people (10-24 years old) with brain tumors: results from the international MOBI-Kids study |
Author: | Zumel Marne, Angela Kundi, Michael Castaño-Vinyals, Gemma Alguacil, Juan Petridou, Eleni Th Georgakis, Marios K. Morales Suárez-Varela, María Sadetzki, Siegal Piro, Sara Nagrani, Rajini Filippini, Graziella Hutter, Hans‑Peter Dikshit, Rajesh Woehrer, Adelheid Maule, Milena Weinmann, Tobias Krewski, Daniel Mannetje, Andrea 't Momoli, Franco Lacour, Brigitte Mattioli, Stefano Spinelli, John J. Ritvo, Paul Remen, Thomas Kojimahara, Noriko Eng, Amanda Thurston, Angela Lim, Hyungryul Ha, Mina Yamaguchi, Naohito Mohipp, Charmaine Bouka, Evdoxia Eastman, Chelsea Vermeulen, Roel C. H. Kromhout, Hans Cardis, Elisabeth |
Keywords: | Tumors cerebrals Diagnòstic Brain tumors Diagnosis |
Issue Date: | 3-Mar-2020 |
Publisher: | Springer Verlag |
Abstract: | Introduction: We used data from MOBI-Kids, a 14-country international collaborative case–control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24). Methods: Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location. Results: Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and ‘non-neuroepithelial’ tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/ vomiting was the only combination of symptoms that exceeded a cutof of 50%, with a joint occurrence of 67%. Overall, the median time from frst symptom to diagnosis was 1.42 months (IQR0.53–4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays. Conclusions: This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identifed, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1007/s11060-020-03437-4 |
It is part of: | Journal of Neuro-Oncology, 2020 |
URI: | https://hdl.handle.net/2445/152321 |
Related resource: | http://dx.doi.org/10.1007/s11060-020-03437-4 |
ISSN: | 0167-594X |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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Zumel-Marne2020_Article_ClinicalPresentationOfYoungPeo.pdf | 810.05 kB | Adobe PDF | View/Open |
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