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http://hdl.handle.net/2445/152738
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DC Field | Value | Language |
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dc.contributor.author | Palomo-Guerrero, Marta | - |
dc.contributor.author | Fadó Andrés, Rut | - |
dc.contributor.author | Casas, Maria | - |
dc.contributor.author | Pérez-Montero, Marta | - |
dc.contributor.author | Baena Muñoz, Miguel | - |
dc.contributor.author | Helmer, Patrick O | - |
dc.contributor.author | Domínguez, José Luis | - |
dc.contributor.author | Roig, Aina | - |
dc.contributor.author | Serra i Cucurull, Dolors | - |
dc.contributor.author | Hayen, Heiko | - |
dc.contributor.author | Stenmark, Harald | - |
dc.contributor.author | Raiborg, Camilla | - |
dc.contributor.author | Casals, Núria | - |
dc.date.accessioned | 2020-03-13T12:01:36Z | - |
dc.date.available | 2020-03-13T12:01:36Z | - |
dc.date.issued | 2019-12-23 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/2445/152738 | - |
dc.description.abstract | Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctuate depending on glucose availability or the energy sensor AMP-activated protein kinase (AMPK). We demonstrate in HeLa cells that carnitine palmitoyltransferase 1C (CPT1C) senses malonyl-CoA and enhances LE/Lys anterograde transport by interacting with the endoplasmic reticulum protein protrudin and facilitating the transfer of Kinesin-1 from protrudin to LE/Lys. In cultured mouse cortical neurons, glucose deprivation, pharmacological activation of AMPK or inhibition of malonyl-CoA synthesis decreases LE/Lys abundance at the axon terminal, and shortens axon length in a CPT1C-dependent manner. These results identify CPT1C as a new regulator of anterograde LE/Lys transport in response to malonyl-CoA changes, and give insight into how axon growth is controlled by nutrients. | - |
dc.format.extent | 26 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | eLife Sciences | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.7554/eLife.51063 | - |
dc.relation.ispartof | eLife, 2019, vol. 8, p. e51063 | - |
dc.relation.uri | https://doi.org/10.7554/eLife.51063 | - |
dc.rights | cc-by (c) Palomo-Guerrero, Marta et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Fisiologia) | - |
dc.subject.classification | Carnitina palmitoïl-transferasa 1 | - |
dc.subject.classification | Axons | - |
dc.subject.classification | Lisosomes | - |
dc.subject.other | Carnitine palmitoyltransferase I | - |
dc.subject.other | Axons | - |
dc.subject.other | Lysosomes | - |
dc.title | Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 695363 | - |
dc.date.updated | 2020-03-13T12:01:37Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/788954/EU//CODE | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31868590 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) |
Files in This Item:
File | Description | Size | Format | |
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695363.pdf | 3.55 MB | Adobe PDF | View/Open |
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