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http://hdl.handle.net/2445/152818
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DC Field | Value | Language |
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dc.contributor.author | Alguacil, Javier | - |
dc.contributor.author | Robles i Brau, Jordi | - |
dc.contributor.author | Ràfols Llach, Clara | - |
dc.contributor.author | Bosch, Elisabeth | - |
dc.date.accessioned | 2020-03-16T10:32:23Z | - |
dc.date.available | 2020-03-16T10:32:23Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0952-3499 | - |
dc.identifier.uri | http://hdl.handle.net/2445/152818 | - |
dc.description.abstract | Isothermal titration calorimetry (ITC) is a powerful technique able to evaluate the energetics of target-drug binding within the context of drug discovery. In this work, the interactions of RNAs reproducing bacterial and human ribosomal A-site, with two well-known antibiotic aminoglycosides, Paromomycin and Neomycin, as well as several Neomycin-dinucleotide and -diPNA conjugates, have been evaluated by ITC and the corresponding thermodynamic quantities determined. The comparison of the thermodynamic data of aminoglycosides and their chemical analogues allowed to select Neomycin-diPNA conjugates as the best candidates for antimicrobial activity. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | John Wiley & Sons | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/jmr.2513 | - |
dc.relation.ispartof | Journal of Molecular Recognition, 2016, vol. 29, num. 4, p. 142-150 | - |
dc.relation.uri | https://doi.org/10.1002/jmr.2513 | - |
dc.rights | (c) John Wiley & Sons, 2016 | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Calorimetria | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.classification | RNA | - |
dc.subject.classification | Termodinàmica | - |
dc.subject.other | Calorimetry | - |
dc.subject.other | Antibiotics | - |
dc.subject.other | RNA | - |
dc.subject.other | Thermodynamics | - |
dc.title | Binding thermodynamics of paromomycin, neomycin, neomycin-dinucleotide and -diPNA conjugates to bacterial and human rRNA | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 656691 | - |
dc.date.updated | 2020-03-16T10:32:24Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
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656691.pdf | 195.51 kB | Adobe PDF | View/Open |
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