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http://hdl.handle.net/2445/153218
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DC Field | Value | Language |
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dc.contributor.author | Cozzi, Salvatore | - |
dc.contributor.author | Jamal, Dina Najjari | - |
dc.contributor.author | Slocker, Andrea | - |
dc.contributor.author | Laplana, Maria | - |
dc.contributor.author | García-Tejedor, Amparo | - |
dc.contributor.author | Krengli, Marco | - |
dc.contributor.author | Guedea Edo, Ferran | - |
dc.contributor.author | Gutiérrez Miguélez, Cristina | - |
dc.date.accessioned | 2020-03-20T13:00:40Z | - |
dc.date.available | 2020-03-20T13:00:40Z | - |
dc.date.issued | 2019-04-01 | - |
dc.identifier.issn | 1689-832X | - |
dc.identifier.uri | http://hdl.handle.net/2445/153218 | - |
dc.description.abstract | Purpose: breast-conserving treatment (BCT) have emerged as an alternative to mastectomy in patients with ipsilateral breast tumor recurrence (IBTR). We evaluated survival outcomes and treatment-related toxicity in a series of 40 patients with IBTR, who underwent tumorectomy plus interstitial brachytherapy (APBI) as a salvage treatment. Material and methods: retrospective analysis included 40 patients diagnosed with IBTR and treated with intraoperative (26 patients) or post-operative (14 patients) multicatheter brachytherapy for APBI at our institution between June 2002 and October 2017. We assessed cosmesis, toxicity, overall survival (OS), and cancer-specific survival (CSS). Results: tumorectomy was performed in all cases, including intraoperative tumor margin assessment and sentinel node biopsy. Median age was 65 years (range, 41-92). The total prescribed dose was 32 Gy (8 fractions) in 19 patients and 34 Gy (10 fractions) in 20 patients. One elderly patient (age 92) received a single fraction of 16 Gy. Median follow-up was 61.5 months (range, 6-153). A median of 14 tubes were inserted. Mean treated V100 was 115 cc. Two patients developed a second relapse at 3 and 5 years after salvage treatment: one patient underwent salvage mastectomy and remains alive 10 years after brachytherapy, and the second one developed both local relapse and bone metastasis. The disease is stable at present. Five-year OS and CSS rates were 85.3% and 97.5%, respectively. Two patients died from cancer-related causes. Acute and late toxicity rates were low; seven patients developed acute infectious mastitis. Late fibrosis > grade 3 and late mastitis were observed in 14 and 6 cases, respectively. Conclusions: second BCT with APBI as a salvage treatment in ipsilateral breast recurrence achieves good local disease control, with a satisfactory toxicity profile compared to mastectomy. This approach seems to be safe and effective, although more data from randomized trials are needed. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Polish Brachytherapy Society | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.5114/jcb.2019.84689 | - |
dc.relation.ispartof | Journal of Contemporary Brachytherapy, 2019, vol. 11, num. 2, p. 101-107 | - |
dc.relation.uri | https://doi.org/10.5114/jcb.2019.84689 | - |
dc.rights | (c) Polish Brachytherapy Society, 2019 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Braquiteràpia | - |
dc.subject.classification | Estudi de casos | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Radioisotope brachytherapy | - |
dc.subject.other | Case studies | - |
dc.title | Second breast-conserving therapy with interstitial brachytherapy (APBI) as a salvage treatment in ipsilateral breast tumor recurrence: a retrospective study of 40 patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 692640 | - |
dc.date.updated | 2020-03-20T13:00:40Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31139217 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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692640.pdf | 548.87 kB | Adobe PDF | View/Open |
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