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http://hdl.handle.net/2445/153320
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DC Field | Value | Language |
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dc.contributor.author | Lanzalaco, Sonia | - |
dc.contributor.author | Sirés Sadornil, Ignacio | - |
dc.contributor.author | Sabatino, Maria Antonietta | - |
dc.contributor.author | Dispenza, Clelia | - |
dc.contributor.author | Scialdone, Onofrio | - |
dc.contributor.author | Galia, Alessandro | - |
dc.date.accessioned | 2020-03-23T09:38:44Z | - |
dc.date.available | 2020-03-23T09:38:44Z | - |
dc.date.issued | 2017-06-19 | - |
dc.identifier.issn | 0013-4686 | - |
dc.identifier.uri | http://hdl.handle.net/2445/153320 | - |
dc.description.abstract | Recently, electro-Fenton (EF) process has been shown as a promising, facile, effective, low cost and environmentally-friendly alternative for synthesizing polymer nanogels suitable as biocompatible nanocarriers for emerging biomedical applications. Here, the electrochemically-assisted modification of poly(vinylpyrrolidone) (PVP) by EF process was studied to assess the role of key operation parameters for a precise modulation of polymer crosslinking and its functionalization with -COOH and succinimide groups. The dimensions of the nanogels, in terms of hydrodynamic radius (Rh) and weight-average molecular weight (Mw), can be tuned up by controlling the electrolysis time, current density (j) and PVP and Fe2+ concentrations, as demonstrated via dynamic and static light scattering and gel permeation chromatography analysis. Using PVP at 0.25 wt.%, Fe2+ at 0.5-1.0 mmol dm-3 and low j, short treatment times induced intramolecular crosslinking with chain scission, allowing size reduction of PVP particles from 24 to 9-10 nm. Longer reaction times and higher PVP and Fe2+ contents favored intermolecular crosslinking ending in Mw values higher than the initial 3.95×105 g mol-1. An excessive ¿OH dose from a too high circulated charge (Q), i.e., too prolonged electrolysis time even at low j or too high j even for short time, promoted intramolecular crosslinking (Rh ~ 10-12 nm) along with a very significant chain scission probably owing to the loss of mobility of the three-dimensional nanogel network. In conclusion, EF allowed transforming the architecture of linear, inert PVP chains into a functionalized nanogel with -COOH and succinimide groups that have great potential for further conjugation. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.electacta.2017.06.097 | - |
dc.relation.ispartof | Electrochimica Acta, 2017, vol. 246, p. 812-822 | - |
dc.relation.uri | https://doi.org/10.1016/j.electacta.2017.06.097 | - |
dc.rights | cc-by-nc-nd (c) Elsevier Ltd, 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Ciència dels Materials i Química Física) | - |
dc.subject.classification | Oxidació electroquímica | - |
dc.subject.other | Electrolytic oxidation | - |
dc.title | Synthesis of polymer nanogels by electro-Fenton process: investigation of the effect of main operation parameters | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 672699 | - |
dc.date.updated | 2020-03-23T09:38:45Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciència dels Materials i Química Física) |
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672699.pdf | 1.09 MB | Adobe PDF | View/Open |
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