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http://hdl.handle.net/2445/153989
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DC Field | Value | Language |
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dc.contributor.author | Giralt Torroella, Albert | - |
dc.contributor.author | Brito, Verónica | - |
dc.contributor.author | Pardo Muñoz, Mònica | - |
dc.contributor.author | Rubio Abejón, Sara Esmeralda | - |
dc.contributor.author | Marion Poll, Lucile | - |
dc.contributor.author | Martín Ibáñez, Raquel | - |
dc.contributor.author | Zamora-Moratalla, Alfonsa | - |
dc.contributor.author | Bosch, Carles | - |
dc.contributor.author | Ballesteros, Jesús J. | - |
dc.contributor.author | Blasco, Esther | - |
dc.contributor.author | García-Torralba, Aída | - |
dc.contributor.author | Pascual Sánchez, Marta | - |
dc.contributor.author | Pumarola, Martí | - |
dc.contributor.author | Alberch i Vié, Jordi, 1959- | - |
dc.contributor.author | Ginés Padrós, Silvia | - |
dc.contributor.author | Martín, Eduardo D. | - |
dc.contributor.author | Segovia, José Carlos | - |
dc.contributor.author | Soriano García, Eduardo | - |
dc.contributor.author | Canals i Coll, Josep M. | - |
dc.date.accessioned | 2020-03-26T12:09:28Z | - |
dc.date.available | 2020-03-26T12:09:28Z | - |
dc.date.issued | 2020-01-01 | - |
dc.identifier.issn | 0014-4886 | - |
dc.identifier.uri | http://hdl.handle.net/2445/153989 | - |
dc.description.abstract | Currently, molecular, electrophysiological and structural studies delineate several neural subtypes in the hippocampus. However, the precise developmental mechanisms that lead to this diversity are still unknown. Here we show that alterations in a concrete hippocampal neuronal subpopulation during development specifically affect hippocampal-dependent spatial memory. We observed that the genetic deletion of the transcription factor Helios in mice, which is specifically expressed in developing hippocampal calbindin-positive CA1 pyramidal neurons (CB-CA1-PNs), induces adult alterations affecting spatial memory. In the same mice, CA3-CA1 synaptic plasticity and spine density and morphology in adult CB-CA1-PNs were severely compromised. RNAseq experiments in developing hippocampus identified an aberrant increase on the Visinin-like protein 1 (VSNL1) expression in the hippocampi devoid of Helios. This aberrant increase on VSNL1 levels was localized in the CB-CA1-PNs. Normalization of VSNL1 levels in CB-CA1-PNs devoid of Helios rescued their spine loss in vitro. Our study identifies a novel and specific developmental molecular pathway involved in the maturation and function of a CA1 pyramidal neuronal subtype. | - |
dc.format.extent | 18 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.expneurol.2019.113095 | - |
dc.relation.ispartof | Experimental Neurology, 2020, vol. 323, p. 113095 | - |
dc.relation.uri | https://doi.org/10.1016/j.expneurol.2019.113095 | - |
dc.rights | cc by-nc-nd (c) Giralt Torroella et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Neurociències | - |
dc.subject.other | Neurosciences | - |
dc.title | Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 693890 | - |
dc.date.updated | 2020-03-26T12:09:29Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31712124 | - |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
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693890.pdf | 5.87 MB | Adobe PDF | View/Open |
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