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http://hdl.handle.net/2445/154829
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DC Field | Value | Language |
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dc.contributor.author | Petit Roig, Elena | - |
dc.contributor.author | Bosch Hereu, Lluís | - |
dc.contributor.author | Costa i Arnau, Anna M. | - |
dc.contributor.author | Vilarrasa i Llorens, Jaume | - |
dc.date.accessioned | 2020-04-02T09:54:36Z | - |
dc.date.available | 2020-09-06T05:10:26Z | - |
dc.date.issued | 2019-09-14 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | http://hdl.handle.net/2445/154829 | - |
dc.description.abstract | We have developed a conjugation reaction based on the thia-Michael addition to activated triple bonds, which can be an alternative to maleimides, the most commonly used reagents to link thiol groups (of Cys) to drugs and labels. An amino group is converted into its propynamide and, in aqueous media at 37 °C and pH 7.4, Cys derivatives are added. The oxopropene-1,3-diyl linker is formed with excellent Z selectivity without secondary reactions. No exchange with other thiols is observed. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/acs.joc.8b02686 | - |
dc.relation.ispartof | Journal of Organic Chemistry, 2019, vol. 84, num. 17, p. 11170-11176 | - |
dc.relation.uri | https://doi.org/10.1021/acs.joc.8b02686 | - |
dc.rights | (c) American Chemical Society , 2019 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Tiols | - |
dc.subject.classification | Reaccions d'addició | - |
dc.subject.classification | Enllaços químics | - |
dc.subject.classification | Síntesi orgànica | - |
dc.subject.other | Thiols | - |
dc.subject.other | Addition reactions | - |
dc.subject.other | Chemical bonds | - |
dc.subject.other | Organic synthesis | - |
dc.title | (Z)-Oxopropene-1,3-diyl, a linker for the conjugation of the thiol group of cysteine with amino-derivatized drugs | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 692572 | - |
dc.date.updated | 2020-04-02T09:54:36Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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692572.pdf | 728.55 kB | Adobe PDF | View/Open |
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