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http://hdl.handle.net/2445/154912
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DC Field | Value | Language |
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dc.contributor.author | Caro, Carlos | - |
dc.contributor.author | Dalmases Solé, Mariona | - |
dc.contributor.author | Figuerola i Silvestre, Albert | - |
dc.contributor.author | García-Martín, M.L. | - |
dc.contributor.author | Pernia Leal, Manuel | - |
dc.date.accessioned | 2020-04-03T11:35:55Z | - |
dc.date.available | 2020-04-03T11:35:55Z | - |
dc.date.issued | 2017-04-25 | - |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.uri | http://hdl.handle.net/2445/154912 | - |
dc.description.abstract | X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that requires intravenously administration of contrast agents to enhance the sensitivity and visualization of soft tissues. In this work, we have developed a novel CT contrast agent based on ternary Ag-Au-Se chalcogenide nanoparticles. A facile and gentle ligand exchange by using a 3 kDa PEGylated ligand with a dithiol dihydrolipoic as an anchor resulted in highly water-soluble and monodisperse nanoparticles. Moreover, the injected PEGylated ternary NPs presented excellent characteristics as a CT contrast agent with high bioavailability, low cytotoxicity and long blood circulation times with slow uptake by the mononuclear phagocyte system, thus being ideal for in vivo imaging. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Royal Society of Chemistry | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1039/C7NR01110E | - |
dc.relation.ispartof | Nanoscale, 2017, vol. 9, num. 21, p. 7242-7251 | - |
dc.relation.uri | https://doi.org/10.1039/C7NR01110E | - |
dc.rights | (c) Caro, Carlos et al., 2017 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Lligands | - |
dc.subject.classification | Nanopartícules | - |
dc.subject.classification | Tomografia | - |
dc.subject.other | Ligands | - |
dc.subject.other | Nanoparticles | - |
dc.subject.other | Tomography | - |
dc.title | Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood term X-rays computed tomography contrast agents | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 679907 | - |
dc.date.updated | 2020-04-03T11:35:55Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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679907.pdf | 1.22 MB | Adobe PDF | View/Open |
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