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Title: The one year fate of iron oxide coated gold nanoparticles in mice
Author: Kolosnjaj-Tabi, Jelena
Javed, Yasir
Lartigue, Lénaic
Volatron, Jeanne
Elgrabli, Dan
Marangon, Iris
Pugliese, Giammarino
Caron, Benoit
Figuerola i Silvestre, Albert
Luciani, Nathalie
Pellegrino, Teresa
Alloyeau, Damien
Gazeau, Florence
Keywords: Nanopartícules
Issue Date: 13-Jul-2015
Publisher: American Chemical Society
Abstract: Safe implementation of nanotechnology and nanomedicine requires an in-depth understanding of the life cycle of nanoparticles in the body. Here, we investigate the long-term fate of gold/iron oxide heterostructures after intravenous injection in mice. We show these heterostructures degrade in vivo and that the magnetic and optical properties change during the degradation process. These particles eventually eliminate from the body. The comparison of two different coating shells for heterostructures, amphiphilic polymer or polyethylene glycol, reveals the long lasting impact of initial surface properties on the nanocrystal degradability and on the kinetics of elimination of magnetic iron and gold from liver and spleen. Modulation of nanoparticles reactivity to the biological environment by the choice of materials and surface functionalization may provide new directions in the design of multifunctional nanomedicines with predictable fate.
Note: Versió postprint del document publicat a:
It is part of: ACS Nano, 2015, vol. 9, num. 8, p. 7925-7939
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ISSN: 1936-0851
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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