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Title: State-of-the-art in host-derived biomarkers of Chagas disease prognosis and early evaluation of anti-Trypanosoma cruzi treatment response
Author: Cortés Serra, Núria
Losada, Irene
Pinazo, Maria-Jesus
Fernández Becerra, María del Carmen
Gascón i Brustenga, Joaquim
Alonso Padilla, Julio
Keywords: Malaltia de Chagas
Marcadors bioquímics
Chagas' disease
Biochemical markers
Issue Date: 10-Mar-2020
Publisher: Elsevier
Abstract: Chagas disease is caused by infection with the parasite Trypanosoma cruzi, which might lead to a chronic disease state and drive to irreversible damage to the heart and/or digestive tract tissues. Endemic in 21 countries in the Americas, it is the neglected disease with a highest burden in the region. Current estimates point at ~6 million people infected, of which ~30% will progress onto the symptomatic tissue disruptive stage. There is no vaccine but there are two anti-parasitic drugs available: benznidazole and nifurtimox. However, their efficacy is variable at the chronic symptomatic stage and both have frequent adverse effects. Since there are no prognosis markers, drugs should be administered to all T. cruzi-infected individuals in the indeterminate and early symptomatic stages. Nowadays, there are no tests-of-cure either, which greatly undermines patients' follow-up and the search of safer and more efficacious drugs. Therefore, the identification and validation of biomarkers of disease progression and/or treatment response on which to develop tests of prognosis and/or cure is a major research priority. Both parasite- and host-derived markers have been investigated. In the present manuscript we present an updated outlook of the latter.
Note: Versió postprint del document publicat a:
It is part of: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2020, vol. 1886, num. 7
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ISSN: 0925-4439
Appears in Collections:Articles publicats en revistes (ISGlobal)

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