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http://hdl.handle.net/2445/155311
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DC Field | Value | Language |
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dc.contributor.author | Abdel Monaim, Shimaa A. H. | - |
dc.contributor.author | Noki, Sikabwe | - |
dc.contributor.author | Ramchuran, Estelle J. | - |
dc.contributor.author | El-Faham, Ayman | - |
dc.contributor.author | Albericio Palomera, Fernando | - |
dc.contributor.author | de la Torre, Beatriz G. | - |
dc.date.accessioned | 2020-04-14T20:47:11Z | - |
dc.date.available | 2020-04-14T20:47:11Z | - |
dc.date.issued | 2017-09-28 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/2445/155311 | - |
dc.description.abstract | Teixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis. Due to both its structure as a head-to-side chain cyclodepsipeptide and its activity, it has attracted the attention of several research groups. In this regard, a large number of analogs with substitutions in both the cycle and the tail has been described. Here, we report the contribution of the N-terminus residue, N-Me-d-Phe, to the activity of Arg10-teixobactin. On the basis of our findings, we conclude that the N-terminus accepts minimum changes but not the presence of long alkyl chains. The presence of a positive charge is a requirement for the activity of the peptide. Furthermore, acylation of the N-terminus leads to total loss of activity. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/molecules22101632 | - |
dc.relation.ispartof | Molecules, 2017, vol. 22, num. 10, p. 1632 | - |
dc.relation.uri | https://doi.org/10.3390/molecules22101632 | - |
dc.rights | cc-by (c) Abdel Monaim, Shimaa A. H. et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Síntesi de pèptids | - |
dc.subject.classification | Bacteris | - |
dc.subject.classification | Mycobacterium tuberculosis | - |
dc.subject.other | Peptide synthesis | - |
dc.subject.other | Bacteria | - |
dc.subject.other | Mycobacterium tuberculosis | - |
dc.title | Investigation of the N-terminus amino functional of Arg10-Teixobactin | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 681058 | - |
dc.date.updated | 2020-04-14T20:47:12Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28956840 | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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681058.pdf | 711.58 kB | Adobe PDF | View/Open |
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