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Title: Central blood pressure variability is increased in hyperternsive patients with target organ damage
Author: Sierra, Alejandro de la
Pareja, Julia
Yun, Sergi
Acosta, Eva
Aiello, Francesco
Oliveras, Anna
Vázquez, Susana
Armario García, Pedro
Blanch, Pedro
Sierra, Cristina
Calero, Francesca
Fernández-Llama, Patricia
Keywords: Hipertensió
Pressió sanguínia
Malalties cardiovasculars
Blood pressure
Cardiovascular diseases
Issue Date: Feb-2018
Publisher: American Society for Clinical Investigation
Abstract: We aimed to evaluate the association of aortic and brachial short-term blood pressure variability (BPV) with the presence of target organ damage (TOD) in hypertensive patients. One-hundred seventy-eight patients, aged 57 ± 12 years, 33% women were studied. TOD was defined by the presence of left ventricular hypertrophy on echocardiogram, microalbuminuria, reduced glomerular filtration rate, or increased aortic pulse wave velocity. Aortic and brachial BPV was assessed by 24-hour ambulatory BP monitoring (Mobil-O-Graph). TOD was present in 92 patients (51.7%). Compared to those without evidence of TOD, they had increased night-to-day ratios of systolic and diastolic BP (both aortic and brachial) and heart rate. They also had significant increased systolic BPV, as measured by both aortic and brachial daytime and 24-hours standard deviations and coefficients of variation, as well as for average real variability. Circadian patterns and short-term variability measures were very similar for aortic and brachial BP. We conclude that BPV is increased in hypertensive-related TOD. Aortic BPV does not add relevant information in comparison to brachial BPV.
Note: Reproducció del document publicat a:
It is part of: Journal of Clinical Investigation, 2018, vol. 20, num. 2, p. 266-272
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ISSN: 0021-9738
Appears in Collections:Articles publicats en revistes (Medicina)

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