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http://hdl.handle.net/2445/155477
Title: | Potential role of aminoprocalcitonin in the pathogenesis of alzheimer disease |
Author: | Tavares, Eva Antequera, Desiree López González, Irene Ferrer, Isidro (Ferrer Abizanda) Miñano, Francisco J. Carro, Eva |
Keywords: | Malaltia d'Alzheimer Etiologia Calcitonina Metabolisme Alzheimer's disease Etiology Calcitonin Metabolism |
Issue Date: | 1-Oct-2016 |
Publisher: | Elsevier |
Abstract: | Increasing evidence suggests that inflammatory responses cause brain atrophy and play a prominent and early role in the progression of Alzheimer disease. Recent findings show that the neuroendocrine peptide aminoprocalcitonin (NPCT) plays a critical role in the development of systemic inflammatory response; however, the presence, possible function, regulation, and mechanisms by which NPCT may be involved in Alzheimer disease neuropathology remain unknown. We explored the expression of NPCT and its interaction with amyloid-b (Ab), and proinflammatory and neurogenic effects. By using brain samples of Alzheimer disease patients and APP/PS1 transgenic mice, we evaluated the potential role of NPCT on Ab-related pathology. We found that NPCT is expressed in hippocampal and cortical neurons and Ab-induced up-regulation of NPCT expression. Peripherally administered antibodies against NPCT decreased microglial activation, decreased circulating levels of proinflammatory cytokines, and prevented Ab-induced neurotoxicity in experimental models of Alzheimer disease. Remarkably, anti-NPTC therapy resulted in a significant improvement in the behavioral status of APP/PS1 mice. Our results indicate a central role of NPCT in Alzheimer disease pathogenesis and suggest NPCT as a potential biomarker and therapeutic target. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.ajpath.2016.06.006 |
It is part of: | American Journal of Pathology, 2016, vol. 186, num. 10, p. 2723-2735 |
URI: | http://hdl.handle.net/2445/155477 |
Related resource: | https://doi.org/10.1016/j.ajpath.2016.06.006 |
ISSN: | 0002-9440 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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