Please use this identifier to cite or link to this item:
Title: Sporadic Creutzfeldt-Jakob disease with glial PrPRes nuclear and perinuclear immunoreactivity
Author: Fernández-Vega, Iván
Diaz-Lucena, Daniela
Azkune Calle, Itxaso
Geijo, Maria
Juste, Ramón A.
Llorens Torres, Franc
Vicente Etxenausia, Ikerne
Santos-Juanes, Jorge
Zarranz, Juan J.
Ferrer, Isidro (Ferrer Abizanda)
Keywords: Malaltia de Creutzfeldt-Jakob
Creutzfeldt-Jakob disease
Issue Date: 1-Oct-2018
Publisher: Wiley
Abstract: Proteinase K-resistant prion protein (PrPRes ) nuclear and perinuclear immunoreactivity in oligodendrocytes of the frontal cortex is found in one case of otherwise typical sporadic Creutzfeldt-Jakob disease (sCJD) type VV2a. The PrP nature of the inclusions is validated with several anti-PrP antibodies directed to amino acids 130-160 (12F10), 109-112 (3F4), 97-102 (8G8) and the octarepeat region (amino acids 59-89: SAF32). Cellular identification and subcellular localization were evaluated with double- and triple-labeling immunofluorescence and confocal microscopy using antibodies against PrP, glial markers, and histone H3. Based on review of the literature and our own experience, this is a very odd situation that deserves further validation in other cases. Keywords: Creutzfeldt-Jakob disease; astrocytes; oligodendrocytes; prion.
Note: Versió postprint del document publicat a:
It is part of: Neuropathology, 2018, vol. 38, num. 5, p. 561-567
Related resource:
ISSN: 0919-6544
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
689454.pdf910.64 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.