Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/155518
Title: | Sporadic Creutzfeldt-Jakob disease with glial PrPRes nuclear and perinuclear immunoreactivity |
Author: | Fernández-Vega, Iván Diaz-Lucena, Daniela Azkune Calle, Itxaso Geijo, Maria Juste, Ramón A. Llorens Torres, Franc Vicente Etxenausia, Ikerne Santos-Juanes, Jorge Zarranz, Juan J. Ferrer, Isidro (Ferrer Abizanda) |
Keywords: | Malaltia de Creutzfeldt-Jakob Neuròglia Prions Proteïnes Metabolisme Patologia Creutzfeldt-Jakob disease Neuroglia Prions Proteins Metabolism Pathology |
Issue Date: | 1-Oct-2018 |
Publisher: | Wiley |
Abstract: | Proteinase K-resistant prion protein (PrPRes ) nuclear and perinuclear immunoreactivity in oligodendrocytes of the frontal cortex is found in one case of otherwise typical sporadic Creutzfeldt-Jakob disease (sCJD) type VV2a. The PrP nature of the inclusions is validated with several anti-PrP antibodies directed to amino acids 130-160 (12F10), 109-112 (3F4), 97-102 (8G8) and the octarepeat region (amino acids 59-89: SAF32). Cellular identification and subcellular localization were evaluated with double- and triple-labeling immunofluorescence and confocal microscopy using antibodies against PrP, glial markers, and histone H3. Based on review of the literature and our own experience, this is a very odd situation that deserves further validation in other cases. Keywords: Creutzfeldt-Jakob disease; astrocytes; oligodendrocytes; prion. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1111/neup.12505 |
It is part of: | Neuropathology, 2018, vol. 38, num. 5, p. 561-567 |
URI: | https://hdl.handle.net/2445/155518 |
Related resource: | https://doi.org/10.1111/neup.12505 |
ISSN: | 0919-6544 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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