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Title: Cardiovascular risk in early psychosis. Relationship with inflammation and clinical features 6 months after diagnosis
Author: Barcones Molero, Maria Fe
MacDowell, Karina S.
García-Bueno, Borja
Bioque Alcázar, Miquel
Gutiérrez-Galve, Leticia
González-Pinto, Ana
Parellada, Maria José
Bobes García, Julio
Bernardo Arroyo, Miquel
Lobo, Antonio
Leza, Juan C
Keywords: Psicosi
Malalties cardiovasculars
Cardiovascular diseases
Issue Date: 1-May-2018
Publisher: Oxford University Press
Abstract: Background: We aimed to investigate the state of cardiovascular risk/protection factors in early psychosis patients. Methods: A total 119 subjects were recruited during the first year after their first episode of psychosis. Eighty-five of these subjects were followed during the next 6 months. Cardiovascular risk/protection factors were measured in plasma and co-variated by sociodemographic/clinical characteristics. Multiple linear regression models detected the change of each biological marker from baseline to follow-up in relation to clinical scales, antipsychotic medication, and pro-/antiinflammatory mediators. Results: Glycosylated hemoglobin is a state biomarker in first episode of psychosis follow-up patients and inversely correlated to the Global Assessment of Functioning scale. We found opposite alterations in the levels of VCAM-1 and E-selectin in first episode of psychosis baseline conditions compared with control that were absent in the first episode of psychosis follow-up group. Adiponectin levels decreased in a continuum in both pathological time points studied. E-Selectin plasma levels were inversely related to total antipsychotic equivalents and adiponectin levels inversely co-related to the Global Assessment of Functioning scale. Finally, adiponectin levels were directly related to antiinflammatory nuclear receptor PPARγ expression in first episode of psychosis baseline conditions and to proinflammatory nuclear factor nuclear factor κB activity in follow-up conditions, respectively. Conclusions: Our results support the need for integrating cardiovascular healthcare very early after the first episode of psychosis.
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It is part of: International Journal of Neuropsychopharmacology, 2018, vol. 21, num. 5, p. 410-422
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ISSN: 1461-1457
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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