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Title: | Low-dose spironolactone-pioglitazone-metformin normalizes circulating fetuin-a concentrations in adolescent girls with polycystic ovary syndrome |
Author: | Díaz, Marta Gallego Escuredo, José Miguel López Bermejo, Abel Zegher, Francis de Villarroya i Gombau, Francesc Ibáñez, Lourdes |
Keywords: | Malalties de l'ovari Endocrinologia Noies adolescents Ovary diseases Endocrinology Teenage girls |
Issue Date: | 19-Jul-2018 |
Publisher: | Hindawi |
Abstract: | BACKGROUND: Fetuin-A is a glycoprotein produced in the liver and related to metabolic syndrome; fetuin-A secretion is divergently regulated in different pathological conditions. In girls with polycystic ovary syndrome (PCOS), insulin sensitization results in a more favorable endocrine-metabolic outcome than oral contraception; we assessed whether those differences are underscored by changes in circulating fetuin-A. METHODS: Fetuin-A concentration endocrine-metabolic markers and hepatovisceral fat were measured longitudinally in 35 PCOS girls [age, 16 yr; body mass index (BMI), 23 kg/m2] randomized to receive either oral contraception [ethinylestradiol-levonorgestrel (n = 18)] or a low-dose combination of spironolactone, pioglitazone, and metformin (SPIOMET, n = 17) over 12 months. Healthy adolescent girls (age- and BMI-matched) were used as controls (n = 25). RESULTS: Pretreatment fetuin-A serum levels in PCOS girls were lower than those in controls. After 12 months on treatment, fetuin-A raised to control levels only in the SPIOMET subgroup (P = 0.009, versus oral contraception); this increase was paralleled by a healthier metabolic profile with less hepatic fat (by MRI); baseline serum fetuin-A as well as the changes over 12 months was inversely related to hepatic adiposity. CONCLUSIONS: A low-dose combination of insulin sensitizers and an antiandrogen-but not oral contraception-normalizes fetuin-A levels in adolescent girls with PCOS. This trial is registered with ISRCTN29234515. |
Note: | Reproducció del document publicat a: https://doi.org/10.1155/2018/4192940 |
It is part of: | International Journal Of Endocrinology, 2018, vol. 2018 |
URI: | http://hdl.handle.net/2445/156082 |
Related resource: | https://doi.org/10.1155/2018/4192940 |
ISSN: | 1687-8337 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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