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https://hdl.handle.net/2445/156117| Title: | OptoGluNAM4.1, a Photoswitchable allosteric antagonist for real-time control of mGlu4 receptor activity |
| Author: | Rovira, Xavier Trapero, Ana Pittolo, Silvia Zussy, Charleine Faucherre, Adèle Jopling, Chris Giraldo, Jesús Pin, Jean-Philippe Gorostiza Langa, Pablo Ignacio Goudet, Cyril Llebaria Soldevila, Amadeu |
| Keywords: | Sistema nerviós Dolor crònic Nervous system Chronic pain |
| Issue Date: | 18-Aug-2016 |
| Publisher: | Elsevier |
| Abstract: | OptoGluNAM4.1, a negative allosteric modulator (NAM) of metabotropic glutamate receptor 4 (mGlu4) contains a reactive group that covalently binds to the receptor and a blue-light-activated, fast-relaxing azobenzene group that allows reversible receptor activity photocontrol in vitro and in vivo. OptoGluNAM4.1 induces light-dependent behavior in zebrafish and reverses the activity of the mGlu4 agonist LSP4-2022 in a mice model of chronic pain, defining a photopharmacological tool to better elucidate the physiological roles of the mGlu4 receptor in the nervous system. |
| It is part of: | Cell Chemical Biology, 2016, vol. 23, num. 8 p. 929-934 |
| URI: | https://hdl.handle.net/2445/156117 |
| Related resource: | https://doi.org/10.1016/j.chembiol.2016.06.013 |
| Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| L01_2016_Cell Chemical Biology_23_929_OA.pdf | 277.55 kB | Adobe PDF | View/Open |
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