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DC Field | Value | Language |
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dc.contributor.author | Xargay i Torrent, Sílvia | - |
dc.contributor.author | Espuña Capote, Núria | - |
dc.contributor.author | Montesinos Costa, Mercè | - |
dc.contributor.author | Prats Puig, Anna | - |
dc.contributor.author | Carreras Badosa, Gemma | - |
dc.contributor.author | Díaz Roldán, Ferran | - |
dc.contributor.author | Zegher, Francis de | - |
dc.contributor.author | Ibáñez Toda, Lourdes | - |
dc.contributor.author | Bassols, Judit | - |
dc.contributor.author | López Bermejo, Abel | - |
dc.date.accessioned | 2020-04-21T22:06:55Z | - |
dc.date.available | 2020-04-21T22:06:55Z | - |
dc.date.issued | 2018-12-14 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/156561 | - |
dc.description.abstract | Although alkaline phosphatase (ALP) correlates with cardiovascular risk in adults, there are no studies in children. We evaluated the association between serum ALP levels, calcium-phosphorus product (Ca*P) and cardiovascular risk markers in healthy children. Children aged 7.9 ± 1.4 (n = 379) were recruited in this cross-sectional study. The main outcome measures were systolic and diastolic blood pressure (SBP and DBP) and carotid intima-media thickness (cIMT). Additional assessments were body-mass index (BMI), waist circumference, homeostatic model assessment of insulin resistance (HOMA-IR) and fasting lipids, ALP, serum calcium, phosphorus and Ca*P. ALP was directly correlated with BMI (p < 0.0001), waist circumference (p < 0.0001), SBP (p < 0.0001), cIMT (p = 0.005), HOMA-IR (p < 0.0001), and fasting triglycerides (p = 0.0001). Among them, in children with Ca*P values above the median the associations were BMI (r = 0.231; p = 0.001), waist (r = 0.252; p < 0.0001), SBP (r = 0.324; p < 0.0001), cIMT (r = 0.248; p = 0.001) and HOMA-IR (r = 0.291; p < 0.0001)]. ALP independently associated with SBP (β = 0.290, p < 0.001) and cIMT (β = 0.179, p = 0.013) in children with higher Ca*P, after adjusting for confounding variables. Circulating ALP is associated with a more adverse cardiovascular profile in children with higher Ca*P. We suggest that serum ALP and Ca*P levels could contribute to the assessment of risk for cardiovascular disease in children. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-35973-5 | - |
dc.relation.ispartof | Scientific Reports, 2018, vol. 8, num. 1, p. 17864 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-018-35973-5 | - |
dc.rights | cc-by (c) Xargay i Torrent, Sílvia et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Malalties cardiovasculars | - |
dc.subject.classification | Factors de risc en les malalties | - |
dc.subject.classification | Malalties dels infants | - |
dc.subject.other | Cardiovascular diseases | - |
dc.subject.other | Risk factors in diseases | - |
dc.subject.other | Children's diseases | - |
dc.title | Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 686335 | - |
dc.date.updated | 2020-04-21T22:06:55Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30552346 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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686335.pdf | 1.29 MB | Adobe PDF | View/Open |
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