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http://hdl.handle.net/2445/158146
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DC Field | Value | Language |
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dc.contributor.author | Hereu, Mercè | - |
dc.contributor.author | Ramos Romero, Sara | - |
dc.contributor.author | Busquets, Cristina | - |
dc.contributor.author | Atienza, Lidia | - |
dc.contributor.author | Amézqueta, Susana | - |
dc.contributor.author | Miralles Pérez, Bernat | - |
dc.contributor.author | Nogués, M. Rosa | - |
dc.contributor.author | Méndez, Lucía | - |
dc.contributor.author | Medina, Isabel | - |
dc.contributor.author | Torres Simón, Josep Lluís | - |
dc.date.accessioned | 2020-04-30T10:34:36Z | - |
dc.date.available | 2020-04-30T10:34:36Z | - |
dc.date.issued | 2019-09-01 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/158146 | - |
dc.description.abstract | Food contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of d-fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the development of fat-induced pre-diabetes. Male Sprague Dawley (SD) rats were fed a standard diet, or a high-fat (HF) diet supplemented with d-fagomine, EPA/DHA 1:1, a combination of both, or neither, for 24 weeks. The variables measured were fasting glucose and glucose tolerance, plasma insulin, liver inflammation, fecal/cecal gut bacterial subgroups and short-chain fatty acids (SCFAs). The animals supplemented with d-fagomine alone and in combination with ω-3 PUFAs accumulated less fat than those in the non-supplemented HF group and those given only ω-3 PUFAs. The combined supplements attenuated the high-fat-induced incipient insulin resistance (IR), and liver inflammation, while increasing the cecal content, the Bacteroidetes:Firmicutes ratio and the populations of Bifidobacteriales. The functional effects of the combination of d-fagomine and EPA/DHA 1:1 against gut dysbiosis and the very early metabolic alterations induced by a high-fat diet are mainly those of d-fagomine complemented by the anti-inflammatory action of ω-3 PUFAs. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-52678-5 | - |
dc.relation.ispartof | Scientific Reports, 2019, vol. 9, p. 16628 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-019-52678-5 | - |
dc.rights | cc-by (c) Hereu, Mercè et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Microbiota intestinal | - |
dc.subject.classification | Diabetis | - |
dc.subject.other | Gastrointestinal microbiome | - |
dc.subject.other | Diabetes | - |
dc.title | Effects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 695830 | - |
dc.date.updated | 2020-04-30T10:34:37Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31719544 | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
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695830.pdf | 1.91 MB | Adobe PDF | View/Open |
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