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dc.contributor.authorHereu, Mercè-
dc.contributor.authorRamos Romero, Sara-
dc.contributor.authorBusquets, Cristina-
dc.contributor.authorAtienza, Lidia-
dc.contributor.authorAmézqueta, Susana-
dc.contributor.authorMiralles Pérez, Bernat-
dc.contributor.authorNogués, M. Rosa-
dc.contributor.authorMéndez, Lucía-
dc.contributor.authorMedina, Isabel-
dc.contributor.authorTorres Simón, Josep Lluís-
dc.description.abstractFood contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of d-fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the development of fat-induced pre-diabetes. Male Sprague Dawley (SD) rats were fed a standard diet, or a high-fat (HF) diet supplemented with d-fagomine, EPA/DHA 1:1, a combination of both, or neither, for 24 weeks. The variables measured were fasting glucose and glucose tolerance, plasma insulin, liver inflammation, fecal/cecal gut bacterial subgroups and short-chain fatty acids (SCFAs). The animals supplemented with d-fagomine alone and in combination with ω-3 PUFAs accumulated less fat than those in the non-supplemented HF group and those given only ω-3 PUFAs. The combined supplements attenuated the high-fat-induced incipient insulin resistance (IR), and liver inflammation, while increasing the cecal content, the Bacteroidetes:Firmicutes ratio and the populations of Bifidobacteriales. The functional effects of the combination of d-fagomine and EPA/DHA 1:1 against gut dysbiosis and the very early metabolic alterations induced by a high-fat diet are mainly those of d-fagomine complemented by the anti-inflammatory action of ω-3 PUFAs.-
dc.format.extent12 p.-
dc.publisherNature Publishing Group-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofScientific Reports, 2019, vol. 9, p. 16628-
dc.rightscc-by (c) Hereu, Mercè et al., 2019-
dc.sourceArticles publicats en revistes (Enginyeria Química i Química Analítica)-
dc.subject.classificationMicrobiota intestinal-
dc.subject.otherGastrointestinal microbiome-
dc.titleEffects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet-
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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