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http://hdl.handle.net/2445/158153
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DC Field | Value | Language |
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dc.contributor.author | Carreras Badosa, Gemma | - |
dc.contributor.author | Remesar Betlloch, Xavier | - |
dc.contributor.author | Prats Puig, Anna | - |
dc.contributor.author | Xargay i Torrent, Sílvia | - |
dc.contributor.author | Lizarraga Mollinedo, Esther | - |
dc.contributor.author | Zegher, Francis de | - |
dc.contributor.author | Ibáñez, Lourdes | - |
dc.contributor.author | Bassols, Judit | - |
dc.contributor.author | López Bermejo, Abel | - |
dc.date.accessioned | 2020-04-30T13:41:32Z | - |
dc.date.available | 2020-04-30T13:41:32Z | - |
dc.date.issued | 2019-05-15 | - |
dc.identifier.issn | 0031-3998 | - |
dc.identifier.uri | http://hdl.handle.net/2445/158153 | - |
dc.description.abstract | Background: Although prenatal and postnatal programming of metabolic diseases in adulthood is well established, the mechanims underpinning metabolic programming are not. DLK1, a key regulator of fetal development, inhibits adipocyte differentiation and restricts fetal growth. Methods: Assess Dlk1 expression in Wistar rat model of catch-up growth following intrauterine restriction. Dams fed ad libitum deliverd control pups (C) and dams on a 50% calorie-restricted diet delivered pups with low birth weight (R). Restricted offspring fed a standard rat chow showd catch-up growth (R/C) but those kept on a calorie-restricted diet did not (R/R). Results: Decreased Dlk1 expression was observed in adipose tissue and skeletal muscle of R/C pups along with excessive visceral fat accumulation, decreased circulating adiponectin, increased triglycerides and HOMA-IR (from p<0.05 to p<0.001). Moreover, in R/C pups, the reduced Dlk1 expression in adipose tissue and skeletal muscle correlated with visceral fat (r= -0.820; p<0.0001) and HOMA-IR (r= -0.745; p=0.002). Conclusions: Decreased Dlk1 expression relates to visceral fat expansion and insulin resistance in a rat model of catch-up growth following prenatal growth restriction. Modulation of Dlk1 expression could be among the targets of the early prevention of fetal preogramming of adult metabolic disorders. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/s41390-019-0428-2 | - |
dc.relation.ispartof | Pediatric Research, 2019, vol. 86, p. 195-201 | - |
dc.relation.uri | https://doi.org/10.1038/s41390-019-0428-2 | - |
dc.rights | (c) International Pediatric Research Foundation, 2019 | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Medicina prenatal | - |
dc.subject.classification | Trastorns del metabolisme | - |
dc.subject.classification | Rates (Animals de laboratori) | - |
dc.subject.other | Prenatal medicine | - |
dc.subject.other | Disorders of metabolism | - |
dc.subject.other | Rats as laboratory animals | - |
dc.title | Dlk1 expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 690073 | - |
dc.date.updated | 2020-04-30T13:41:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31091532 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
Files in This Item:
File | Description | Size | Format | |
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690073.pdf | 1.41 MB | Adobe PDF | View/Open |
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