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http://hdl.handle.net/2445/158439| Title: | Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells |
| Author: | Carpéné, Christian Garcia-Vicente, Silvia Serrano, Marta Martí, Luc Belles, Chloé Royo Expósito, Miriam Galitzky, Jean Zorzano Olarte, Antonio Testar, Xavier |
| Keywords: | Teixit adipós Resistència a la insulina Obesitat Adipose tissues Insulin resistance Obesity |
| Issue Date: | 15-Apr-2017 |
| Publisher: | Baishideng Publishing Group Inc |
| Abstract: | This study investigates in murine and human adipocytes the antilipolytic properties of a conjugate of benzylamine and decavanadate (B6V10), already reported to lower hyperglycaemia in diabetic rodents. Data indicated that the conjugate dose-dependently inhibited submaximal activation of lipolysis in all the species studied. Such antilipolytic action deals with the in vivo FFA-lowering properties already described for B6V10 in diabetic rats. B6V10 also activated lipogenesis and glucose transport in fat cells. B6V10 should therefore be useful in preventing the lipotoxicity constituted by the unrestrained lipolytic activity of insulin-resistant adipocytes in obese individuals presenting type 2 diabetes, a state named diabesity. |
| Note: | Reproducció del document publicat a: https://doi.org/10.4239/wjd.v8.i4.143 |
| It is part of: | World Journal of Diabetes, 2017, vol. 8, num. 4, p. 143-153 |
| URI: | http://hdl.handle.net/2445/158439 |
| Related resource: | https://doi.org/10.4239/wjd.v8.i4.143 |
| ISSN: | 1948-9358 |
| Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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|---|---|---|---|---|
| 672268.pdf | 1.32 MB | Adobe PDF | View/Open |
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