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http://hdl.handle.net/2445/158458
Title: | DNA-origami-aided lithography for sub-10 nanometer pattern printing |
Author: | Gállego, Isaac Manning, Brendan Prades García, Juan Daniel Mir Llorente, Mònica Samitier i Martí, Josep Eritja i Casadellà, Ramon |
Keywords: | ADN Litografia Nanopartícules Or Origami DNA Lithography Nanoparticles Gold Origami |
Issue Date: | 8-Aug-2017 |
Publisher: | MDPI |
Abstract: | We report the first DNA-based origami technique that can print addressable patterns on surfaces with sub-10 nm resolution. Specifically, we have used a two-dimensional DNA origami as a template (DNA origami stamp) to transfer DNA with pre-programmed patterns (DNA ink) on gold surfaces. The DNA ink is composed of thiol-modified staple strands incorporated at specific positions of the DNA origami stamp to create patterns upon thiol-gold bond formation on the surface (DNA ink). The DNA pattern formed is composed of unique oligonucleotide sequences, each of which is individually addressable. As a proof-of-concept, we created a linear pattern of oligonucleotide-modified gold nanoparticles complementary to the DNA ink pattern. We have developed an in silico model to identify key elements in the formation of our DNA origami-driven lithography and nanoparticle patterning as well as simulate more complex nanoparticle patterns on surfaces. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/proceedings1040325 |
It is part of: | MDPI Proceedings, 2017, vol. 1, num. 4, p. 325 |
URI: | http://hdl.handle.net/2445/158458 |
Related resource: | https://doi.org/10.3390/proceedings1040325 |
ISSN: | 2504-3900 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Electrònica i Biomèdica) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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