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Title: DNA-origami-aided lithography for sub-10 nanometer pattern printing
Author: Gállego, Isaac
Manning, Brendan
Prades García, Juan Daniel
Mir Llorente, Mònica
Samitier i Martí, Josep
Eritja i Casadellà, Ramon
Keywords: ADN
Issue Date: 8-Aug-2017
Publisher: MDPI
Abstract: We report the first DNA-based origami technique that can print addressable patterns on surfaces with sub-10 nm resolution. Specifically, we have used a two-dimensional DNA origami as a template (DNA origami stamp) to transfer DNA with pre-programmed patterns (DNA ink) on gold surfaces. The DNA ink is composed of thiol-modified staple strands incorporated at specific positions of the DNA origami stamp to create patterns upon thiol-gold bond formation on the surface (DNA ink). The DNA pattern formed is composed of unique oligonucleotide sequences, each of which is individually addressable. As a proof-of-concept, we created a linear pattern of oligonucleotide-modified gold nanoparticles complementary to the DNA ink pattern. We have developed an in silico model to identify key elements in the formation of our DNA origami-driven lithography and nanoparticle patterning as well as simulate more complex nanoparticle patterns on surfaces.
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It is part of: MDPI Proceedings, 2017, vol. 1, num. 4, p. 325
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ISSN: 2504-3900
Appears in Collections:Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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