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Title: TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
Author: Caja Puigsubirà, Laia
Dituri, Francesco
Mancarella, Serena
Caballero-Diaz, Daniel
Moustakas, Aristidis
Giannelli, Gianluigi
Fabregat Romero, Isabel
Keywords: Càncer
Fibrosi quística
Matriu extracel·lular
Cèl·lules K
Cystic fibrosis
Extracellular matrix
Killer cells
Issue Date: 26-Apr-2018
Publisher: MDPI
Abstract: Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic response and for the activation of the cancer stroma. Strong evidence suggests that a strong cross-talk exists among TGF-β and the tissue extracellular matrix components. TGF-β is stored in the matrix as part of a large latent complex bound to the latent TGF-β binding protein (LTBP) and matrix binding of latent TGF-β complexes, which is required for an adequate TGF-β function. Once TGF-β is activated, it regulates extracellular matrix remodelling and promotes a fibroblast to myofibroblast transition, which is essential in fibrotic processes. This cytokine also acts on other cell types present in the fibrotic and tumour microenvironment, such as epithelial, endothelial cells or macrophages and it contributes to the cancer-associated fibroblast (CAF) phenotype. Furthermore, TGF-β exerts anti-tumour activity by inhibiting the host tumour immunosurveillance. Aim of this review is to update how TGF-β and the tissue microenvironment cooperate to promote the pleiotropic actions that regulate cell responses of different cell types, essential for the development of fibrosis and tumour progression. We discuss recent evidences suggesting the use of TGF-β chemical inhibitors as a new line of defence against fibrotic disorders or cancer.
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It is part of: International Journal of Molecular Sciences, 2018, vol. 19, num. 5, p. 1294
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ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Fisiològiques)
Publicacions de projectes de recerca finançats per la UE

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